Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model

Hazra, Moumita; Mandal, Dalia Dasgupta; Mandal, Tamal; Rao, B. Prakash; Samaddar, Suman

doi:10.1016/j.jddst.2021.102679

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…The difference between adjusted and predicted R 2 values was ≤0.2 for all response variables, signifying the signal/noise ratio [ 42 ]. This also advocated the adequacy and significance of regression model equations to explain the relationship between independent and dependent variables [ 67 ]. The justification of the adequacy of each model for every response was made by correlation coefficient R 2 , F-value, and p -values evaluated by ANOVA ( Table 3 ) [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the statistical models, the quadratic model was found to be the most statistically significant, with F values (15.67, 31.94, and 5.98) and p -values (0.01, 0.003, 0.05) for PS, EE (%), and yield (%), respectively. Moreover, the adjusted R 2 values viz; 0.9933, 0.8633, and 0.9896 were closed to predicted R 2 with an error ≤ 0.2, advocating the adequacy and significance of regression equations to explain the relationship between independent and dependent variables [ 67 ]. The second polynomial equations obtained were used for describing the mathematical relation between independent and dependent factors (Equations (1)–(3)).…”

Section: Resultsmentioning

confidence: 99%

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Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

et al. 2022

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Combinations of polymers can improve the functional properties of microspheres to achieve desired therapeutic goals. Hence, the present study aimed to formulate Prunus armeniaca gum (PAG) and sodium alginate microsphere for sustained drug release. Blended and coated microspheres were prepared using the ionotropic gelation technique. The effect of polymer concentration variation was studied on the structural and functional properties of formulated microspheres. FTIR, XRD, and thermal analysis were performed to characterize the microspheres. All the formulations were well-formed spherical beads having an average diameter from 579.23 ± 07.09 to 657.67 ± 08.74 μm. Microspheres entrapped drugs within the range 65.86 ± 0.26–83.74 ± 0.79%. The pH-dependent swelling index of coated formulations was higher than blended. FTIR spectra confirmed the presence of characteristic peaks of entrapped Tramadol hydrochloride showing no drug-polymer interaction. In vitro drug release profile showed sustained release following the Korsmeyer-Peppas kinetic model with an R2 value of 0.9803–0.9966. An acute toxicology study employing the oral route in Swiss albino mice showed no signs of toxicity. It can be inferred from these results that blending PAG with sodium alginate can enhance the stability of alginate microspheres and improve its drug release profile by prolonging the release time.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

et al. 2022

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“…Andrographolide (AND), a labdane‐diterpenoid lactone, is the major active compound enriched in Andrographis paniculata, a valuable plant of official Chinese medicine (Peng et al, 2018). ANDRO has several physicochemical and biological properties, including antioxidant, anti‐inflammattion (Tan, Liao, Zhou, & Wong, 2017), immunomodulation, anticancer (Wanandi et al, 2020), cardioprotection (Zhang, Zhu, Wang, & Ju, 2015), and hepatoprotection (Hazra, Mandal, Mandal, Rao, & Samaddar, 2021). Previous researches have well demonstrated the beneficial properties of ANDRO in the CNS, including antineuroinflammation, proneurogenic, and neuroprotective (Xu et al, 2016).…”

Section: Methodsmentioning

confidence: 99%

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

Mokhtari

2022

Phytotherapy Research

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Major depressive disorder (MDD) is a life‐threatening disease that presents several characteristics. The pathogenesis of depression still remains poorly understood. Moreover, the mechanistic interactions of natural components in treating depression to target autophagy and neuroinflammation are yet to be evaluated. This study overviewed the effects of plant‐derived natural components in regulating critical pathways, particularly neuroinflammation and autophagy, associated with depression. A list of natural components, including luteolin, apigenin, hyperforin, resveratrol, salvianolic acid b, isoliquiritin, nobiletin, andrographolide, and oridonin, have been investigated. All peer‐reviewed journal articles were searched by Scopus, MEDLINE, PubMed, Web of Science, and Google Scholar using the appropriated keywords, including depression, neuroinflammation, autophagy, plant, natural components, etc. The neuroinflammation and autophagy dysfunction are critically associated with the pathophysiology of depression. Natural components with higher efficiency and lower complications can be used for targeting neuroinflammation and autophagy. These components with different doses showed the beneficial antidepressant properties in rodents. These can modulate autophagy markers, mainly AMPK, LC3II/LC3I ratio, Beclin‐1. Moreover, they can regulate the NLRP3 inflammasome, resulting in the suppression of proinflammatory cytokines (e.g., IL‐1β and IL‐18). Future in vitro and in vivo studies are required to develop novel therapeutic approaches based on plant‐derived active components to treat MDD.

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“…In vitro release results of different MOX-MS formulations were studied by fitting different kinetic models, such as zero-order or sigmoidal equations, using Origin 2022 software [17,44,45].…”

Section: In Vitro Releasementioning

confidence: 99%

The Effect of Polymer Blends on the In Vitro Release/Degradation and Pharmacokinetics of Moxidectin-Loaded PLGA Microspheres

Zhang,

Yang,

et al. 2023

IJMS

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To investigate the effect of polymer blends on the in vitro release/degradation and pharmacokinetics of moxidectin-loaded PLGA microspheres (MOX-MS), four formulations (F1, F2, F3 and F4) were prepared using the O/W emulsion solvent evaporation method by blending high (75/25, 75 kDa) and low (50/50, 23 kDa) molecular weight PLGA with different ratios. The addition of low-molecular-weight PLGA did not change the release mechanism of microspheres, but sped up the drug release of microspheres and drastically shortened the lag phase. The in vitro degradation results show that the release of microspheres consisted of a combination of pore diffusion and erosion, and especially autocatalysis played an important role in this process. Furthermore, an accelerated release method was also developed to reduce the period for drug release testing within one month. The pharmacokinetic results demonstrated that MOX-MS could be released for at least 60 days with only a slight blood drug concentration fluctuation. In particular, F3 displayed the highest AUC and plasma concentration (AUC0–t = 596.53 ng/mL·d, Cave (day 30-day 60) = 8.84 ng/mL), making it the optimal formulation. Overall, these results indicate that using polymer blends could easily adjust hydrophobic drug release from microspheres and notably reduce the lag phase of microspheres.

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Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model

Cited by 7 publications

References 32 publications

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

The Effect of Polymer Blends on the In Vitro Release/Degradation and Pharmacokinetics of Moxidectin-Loaded PLGA Microspheres

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