Optimization and fabrication of silver nanoparticles to assess the beneficial biological effects besides the inhibition of pathogenic microbes and their biofilms

Nelagadarnahalli, Hema Jayanna; Jacob, Geno Kadwin; Prakash, Dhamodhar; Iska, Rajasekhara Reddy; Iska, Vijaya Bhaskar Reddy; Ameen, Fuad; Rajadurai, Uma Maheshwari; Polachi, Navaneethakrishnan; Jacob, Joe Antony

doi:10.1016/j.inoche.2023.111140

Cited by 9 publications

(3 citation statements)

References 157 publications

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“…Fungal laccase acts as a 4Cu that contains the oxidoreductase-based bio-catalyst, which moves the electrons in the fuel cell. Laccase has been found to transfer noble metals ( Mani and Hameed, 2019 ; Nelagadarnahalli et al, 2023 ).…”

Section: Fungal Catalytic Role In Fcsmentioning

confidence: 99%

Harnessing fungal bio-electricity: a promising path to a cleaner environment

Umar,

Mubeen,

Ali

et al. 2024

Front. Microbiol.

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Integrating fungi into fuel cell systems presents a promising opportunity to address environmental pollution while simultaneously generating energy. This review explores the innovative concept of constructing wetlands as fuel cells for pollutant degradation, offering a practical and eco-friendly solution to pollution challenges. Fungi possess unique capabilities in producing power, fuel, and electricity through metabolic processes, drawing significant interest for applications in remediation and degradation. Limited data exist on fungi’s ability to generate electricity during catalytic reactions involving various enzymes, especially while remediating pollutants. Certain species, such as Trametes versicolor, Ganoderma lucidum, Galactomyces reessii, Aspergillus spp., Kluyveromyce smarxianus, and Hansenula anomala, have been reported to generate electricity at 1200 mW/m3, 207 mW/m2, 1,163 mW/m3, 438 mW/m3, 850,000 mW/m3, and 2,900 mW/m3, respectively. Despite the eco-friendly potential compared to conventional methods, fungi’s role remains largely unexplored. This review delves into fungi’s exceptional potential as fuel cell catalysts, serving as anodic or cathodic agents to mitigate land, air, and water pollutants while simultaneously producing fuel and power. Applications cover a wide range of tasks, and the innovative concept of wetlands designed as fuel cells for pollutant degradation is discussed. Cost-effectiveness may vary depending on specific contexts and applications. Fungal fuel cells (FFCs) offer a versatile and innovative solution to global challenges, addressing the increasing demand for alternative bioenergy production amid population growth and expanding industrial activities. The mechanistic approach of fungal enzymes via microbial combinations and electrochemical fungal systems facilitates the oxidation of organic substrates, oxygen reduction, and ion exchange membrane orchestration of essential reactions. Fungal laccase plays a crucial role in pollutant removal and monitoring environmental contaminants. Fungal consortiums show remarkable potential in fine-tuning FFC performance, impacting both power generation and pollutant degradation. Beyond energy generation, fungal cells effectively remove pollutants. Overall, FFCs present a promising avenue to address energy needs and mitigate pollutants simultaneously.

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Section: Fungal Catalytic Role In Fcsmentioning

confidence: 99%

Harnessing fungal bio-electricity: a promising path to a cleaner environment

Umar,

Mubeen,

Ali

et al. 2024

Front. Microbiol.

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“…AgNPs are considered to have high thermal and electrical conductivities, chemical stability, and are also capable of exhibiting excellent catalytic activity and enhanced Raman scattering [ 66 , 67 ]. Recent research efforts on AgNPs validated that the Ag ions possess antimicrobial, antifungal, anti-inflammatory, and antiviral properties and also have a low toxic effect on humans [ 68 – 70 ]. These unique properties of nanosilver paved the ground for its usage in biomedical applications including drug delivery and cancer therapy.…”

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

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“…Nanotechnology has found applications in various industries, from electronics to energy and medicine, by harnessing the unique properties of nanoscale materials to improve products, processes, and efficiency (Ahmad et al, 2023; Ameen, Tiri, et al, 2023; Cheng et al, 2023; Li, Xia, et al, 2022; Megarajan et al, 2022; Wang et al, 2022; Yuan et al, 2023). Nano‐sized materials and technologies are of paramount importance in healthcare due to their potential to revolutionize drug delivery, diagnostics, and treatment, enabling more precise and effective therapies while minimizing side effects (Al‐Enazi et al, 2023; Ameen, al‐Maary, et al, 2023; Cui et al, 2017; Nelagadarnahalli et al, 2023; Wang, Chen, et al, 2020; Wu et al, 2023; Yang et al, 2022). The oral route of drug delivery is a popular choice due to its convenience and high patient compliance rates.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

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This paper reports on the findings from a study that aimed to identify and characterize the constituents of Ocimum basilicum extract using gas chromatography–mass spectrometry (GC–MS) analysis, as well as assess the physicochemical properties and stability of nanoemulsions formulated with O. basilicum extract. The GC–MS analysis revealed that the O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for use in the biomedical field, with a small and uniform particle size distribution, a negative zeta potential, and high encapsulation efficiency for the O. basilicum extract. The nanoemulsions exhibited spherical morphology and remained physically stable for up to 6 months. In vitro release studies indicated sustained release of the extract from the nanoemulsion formulation compared to the free extract solution. Furthermore, the developed nanoformulation exhibited enhanced anticancer properties against K562 cells while demonstrating low toxicity in normal cells (HEK293). The O. basilicum extract demonstrated antimicrobial activity against Pseudomonas aeruginosa, Candida albicans, and Staphylococcus epidermidis, with a potential synergistic effect observed when combined with the nanoemulsion. These findings contribute to the understanding of the constituents and potential applications of O. basilicum extract and its nanoemulsion formulation in various fields, including healthcare and pharmaceutical industries. Further optimization and research are necessary to maximize the efficacy and antimicrobial activity of the extract and its nanoformulation.Research Highlights This study characterized the constituents of O. basilicum extract and assessed the physicochemical properties and stability of its nanoemulsion formulation. The O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for biomedical applications, with sustained release of the extract, low toxicity, and enhanced anticancer and antimicrobial properties. The findings contribute to the understanding of the potential applications of O. basilicum extract and its nanoemulsion formulation in healthcare and pharmaceutical industries, highlighting the need for further optimization and research.

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Optimization and fabrication of silver nanoparticles to assess the beneficial biological effects besides the inhibition of pathogenic microbes and their biofilms

Cited by 9 publications

References 157 publications

Harnessing fungal bio-electricity: a promising path to a cleaner environment

Harnessing fungal bio-electricity: a promising path to a cleaner environment

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

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