2017
DOI: 10.21065/1920-4159.1000245
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Optimization and Formulation Development of Cefixime Complex Using Spray Drying Technique: DOE Approach

Abstract: Cefixime is BCS class 2/4 drug whose oral absorption is limited by its solubility and/or permeability. The use of HPBCD is proved to be better complexing agent for enhancing solubility as well as permeability of drugs. At the same time spray drying is the one step continuous drying process making it attractive technique for industrial application. Therefore, the current study was undertaken to unite the use of HPBCD and spray drying alongside with optimizing it through Design of Experiments (DOE) approach by m… Show more

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