A huge amount of water is consumed in the textile industry, and the result is the production of a large amount of wastewater. The treatment of such wastewater significantly reduces the pollution load. Oxidation by nano-Fenton reactions (Fe 3+ / H 2 O 2) is a reasonable and cost-efficient process for the remediation of harmful pollutants in wastewater. In the present study, nano-hematite was applied as a source of iron in Fenton's reagent for methylene blue dye removal from wastewater. The effects of different parameters, presence of nano-hematite, hydrogen peroxide concentrations and pH, were optimized using the response surface methodology technique. A Box-Behnken design was applied, and the response (dye removal) was maximized. A maximal dye removal (81.6%) was attained when wastewater was treated at pH 2.5 in the presence of nanohematite and hydrogen peroxide in the amounts of 41 and 388 mg/L, respectively. The model is well fitted and described using the second-order polynomial equation. Moreover, the model validation showed a 97% fit between the theoretical and experimental ones.