Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the determination of glyphosate in human urine after pre-column derivatization with 9-fluorenylmethoxycarbonyl chloride

A Novel Fluorescent Sensor Based on Aptamer and qPCR for Determination of Glyphosate in Tap Water

“…As concerns and studies on the behavior of glyphosate in plants and the environment are growing, several methodologies, including high-performance liquid chromatography (HPLC) [ 12 , 13 ], gas chromatography-mass spectrometry (GC–MS) [ 14 , 15 , 16 ], LC–tandem mass spectrometry (LC-MS/MS) [ 17 , 18 ], liquid chromatography (LC) [ 19 , 20 ], ion chromatography (IC) [ 21 , 22 ], capillary electrophoresis (CE) [ 23 , 24 ], enzyme-linked immunoassays (ELISA) [ 25 , 26 ], fluorescence detection [ 27 , 28 ] and electrochemical luminescence methods [ 29 , 30 ], have been developed to detect its residues. Although the sensitivity and specificity of these methods are relatively high, their shortcomings are also apparent.…”

An analytical method for the determination of glyphosate and aminomethylphosphoric acid using an anionic polar pesticide column and the application in urine and serum from glyphosate poisoning patients

“…Although the derivatization procedures seem an option, timeconsuming and requiring hazardous chemicals in the pretreatment process are their main problems. 2,3,[6][7][8] At present, there are numerous LC-MS/MS methods without derivatization developed for detecting biological uid samples. [9][10][11][12][13][14][15] Although one non-suppressed IC-MS/MS has been developed in our previous report, the organic amine used as the eluent seemed to cause strong suppression in the ionization of the mass spectrometry in positive mode.…”

Determination of Glyphosate, Glufosinate, and Their Major Metabolites in Tea Infusions by Dual-Channel Capillary Electrophoresis following Solid-Phase Extraction

“…It is challenging to simultaneously analyze GLYP, GLUF, and their metabolites in aqueous matrices due to their characteristics of highly polar, lack of chromogenic and fluorescent groups. e methods of liquid chromatography (LC) [20][21][22][23][24][25][26], high-performance liquid chromatography (HPLC) [19], and ultra-high performance liquid chromatography (UHPLC) [27][28][29][30] coupled to tandem mass spectrometry (MS/MS) are commonly used methods, although these methods usually need the derivatization. On the other hand, the derivatization step can be omitted when ion chromatography coupled to tandem mass spectrometry (IC-MS/MS) is used [31].…”