2019
DOI: 10.1016/j.mrgentox.2019.503087
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Optimization and validation of automated dicentric chromosome analysis for radiological/nuclear triage applications

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Cited by 21 publications
(17 citation statements)
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“…dicentric chromosome assay (DCA) [22] was used successfully for dose assessment in incidents like Chernobyl, Goiania, and Fukushima [31][32][33]. However, the DCA technique needs well-trained manpower and is time-consuming which has proved to be the main hindrance in its application [22][23][24]. In the case of MN, the analysis is in uenced by various factors and induced by several agents, thus not radiation speci c [34][35][36][37].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…dicentric chromosome assay (DCA) [22] was used successfully for dose assessment in incidents like Chernobyl, Goiania, and Fukushima [31][32][33]. However, the DCA technique needs well-trained manpower and is time-consuming which has proved to be the main hindrance in its application [22][23][24]. In the case of MN, the analysis is in uenced by various factors and induced by several agents, thus not radiation speci c [34][35][36][37].…”
Section: Discussionmentioning
confidence: 99%
“…The dicentric chromosome assay (DCA) was initially designed in 1962 and is now considered as a "gold standard" of radiation biodosimetry due to its high speci city and being neutral of gender, age, or region [21][22]. However, it is necessary to take note that the DCA technique needs well-trained manpower and is time-consuming [22][23][24].…”
Section: Introductionmentioning
confidence: 99%
“…Hence, many image training classifiers were created to improve the specificity of automated DC analysis algorithm. However, accuracy and efficiency of the automated (unsupervised) DC scoring are still requiring more optimization for accurate dose estimation (41). In this study, we have used the embedded Metafer DCScore algorithm to evaluate the usefulness of the automated DC score.…”
Section: Discussionmentioning
confidence: 99%
“…The actual dose threshold level may vary with the associated trauma and the capacity of the healthcare system. The automated triage mode can provide valuable preliminary diagnostic evidence to segregate between these various categories of risk groups (41). Of particular significance, the automated mode can provide dose estimations that are close to those calculated by the assisted mode in the critical dose exposure range of 2 Gy, which can rapidly identify low risk victims (<2 Gy), who do not require urgent medical attention and high-risk victims (>2 Gy), requiring immediate medical countermeasures and potential therapeutic intervention.…”
Section: Discussionmentioning
confidence: 99%
“…Development of these techniques continues throughout the world 23 25 . High-throughput automated approaches using scanning and imaging software are available to implement these assays 26 28 .…”
Section: Introductionmentioning
confidence: 99%