In recent years, the installation of residential Distributed Energy Resources (DER) that produce (mainly rooftop photovoltaics usually bundled with battery system) or consume (electric heat pumps, controllable loads, electric vehicles) electric power is continuously increasing in Low Voltage (LV) distribution networks. Several technical challenges may arise through the massive integration of DER, which have to be addressed by the distribution grid operator. However, DER can provide certain degree of flexibility to the operation of distribution grids, which is generally performed with temporal shifting of energy to be consumed or injected. This work advances a horizon optimization control framework which aims to efficiently schedule the LV network’s operation in day-ahead scale coordinating multiple DER. The main objectives of the proposed control is to ensure secure LV grid operation in the sense of admissible voltage bounds and rated loading conditions for the secondary transformer. The proposed methodology leans on a multi-period three-phase Optimal Power Flow (OPF) addressed as a nonlinear optimization problem. The resulting horizon control scheme is validated within an LV distribution network through multiple case scenarios with high microgeneration and electric vehicle integration providing admissible voltage limits and avoiding unnecessary active power curtailments.