Optimization Direct Compression’s Co-Processed Excipient Microcrystalline Cellulose PH 102 and Povidone® K 30

Kusuma, Aris Perdana; Fudholi, Achmad; Nugroho, Akhmad Kharis

doi:10.9790/3008-09246569

Cited by 5 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased tapping index indicates worse flow prop- erties of granules. Kollidon K30 is a very hygroscopic material that makes granules sticky (Gonnissen et al, 2008;Kusuma et al, 2014), producing an adverse affect on the granule flow properties. The tapping index of SLD was higher than that of the custom design from the previous research.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, kollidon K30 is a binder which being activated by moisture or water addition on tablet formulation. At the dry form, kollidon K30 has the best flow speeds compared to MCC PH 101 and lactose (Gonnissen et al, 2008;Kusuma et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

“…Such CPE processing attempted to gain the benefits of its constituent components, including the compactibility and good flow properties (Awaluddin et al, 2017;Kusuma et al, 2014;Radojevic dan Zavaliangos, 2017). MCC PH 101, lactose, and kollidon K30 were mixed and spray dryed to obtain CPE powder.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

Kusuma

2018

STI

Self Cite

View full text Add to dashboard Cite

Custom design is a modeling technique that puts forward customized formula in a pharmaceutical formula optimization. The components may be adjusted to the formula constraints. However, these designs sometimes do not accommodate all the components used. In addition, its effectiveness is not necessarily optimal when compared with standard designs such as simplex lattice design (SLD). This study used computerized variations of microcrystalline cellulose PH 101 (MCC PH 101), lactose, and Kollidon K30. Custom design and SLD were compared using the Design Expert software based on previous research data. Hardness and tapping index became test parameters to assess the design effectiveness. The obtained optimum formula was MCC PH 101 : lactose : Kollidon K30 each at 80% : 10% : 10% for SLD. Unlike this finding, the custom design resulted in the absence of lactose proportion in its optimum formula. The predicted custom design had better hardness and tapping index than those of SLD instead.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

Kusuma

2018

STI

Self Cite

View full text Add to dashboard Cite

show abstract

“…The flow rate of granules is influenced by the shape of the granules and the size of the granules (Kusuma et al, 2014). The larger the granule size, the better the flow rate, a good flow rate is also influenced by the cohesiveness of the granules.…”

Section: Flow Ratementioning

confidence: 99%

Untitled

2021

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Kenikir (Cosmos caudatus Kunth) leaves are plants that contain active compounds that function as antioxidants and have the potential as functional drinks. This research was conducted with the aim of knowing the effect of using a combination of acid sources between citric acid and tartaric acid on the characteristics of effervescent granules, to obtain the best combination of acid sources. The stages of this research were the effervescent granule formulation of kenikir leaf extract including the extraction process, microencapsulation, and determination of the formula with a combination of citric acid and tartaric. The method used for the making of effervescent granules was dry granulation method. The factor used in this research was the ratio of the composition of citric acid and tartaric acid including 0%:100%, 25%:75%, 50%:50%, 75%:25% and 100%:0%. The experimental design used in this study was a randomized block design. The data were analyzed by means of variance and continued with the Tukey test if there was an effect of treatment on the results. The results showed that the comparison of the composition of citric acid and tartaric acid had a significant effect on the characteristics of effervescent granules of kenikir leaf extract. The best composition of citric acid and tartaric acid is 75% citric acid and 25% tartaric acid which produces specific gravity 41g/ml, bulk density 0.72gr/ml, flow rate 12, 39gr/second, dissolution time 137seconds, foam volume 8%, pH 6.32 and has antioxidant activity of 21.37%.

show abstract

Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets

et al. 2023

View full text Add to dashboard Cite

Purpose Gastroretentive drug delivery systems (GRDDS) have attracted interest for enhancement of absorption and bioavailability of some drugs. Itopride hydrochloride (ITOP) is a drug used for treatment of gastroesophageal reflux and other gastric motility disorders, but is characterized by narrow absorption window and short in vivo half-life. Therefore, it is expected that its formulation in expanding gastroretentive tablets would increase its gastric residence, thus leading to decreased frequency of administration and increased patient compliance. Methods The direct compression method was used for formulation of tablets. Four different hydrophilic polymers (xanthan gum, sodium alginate, gellan gum, pectin) were screened separately with Avicel 102 and PVP k30 as excipients. The effect of different factors (polymer type and amount, and excipient amount) on the tablet properties such as hardness, friability, thickness, diameter, weight variation, swelling, and in vitro drug dissolution was studied. In addition, swelling test, accelerated stability test, and in vivo study were performed on the optimized formulation. Results Tablets prepared using xanthan gum exhibited favorable properties compared to tablets prepared using the other gums, however increasing the polymer amount led to increased tablet friability. The selected formulation exhibited obvious expansion reaching 17.45 mm and lasting for 24 h, coupled with a sustained release behavior. X-ray scans in human volunteers suggested the residence of the tablet in the stomach for a period of 6 h in fed state. Conclusion Successful preparation of directly compressible ITOP expanding tablets was achieved in this study, which is expected to result in better therapeutic outcome in gastroesophageal reflux.

show abstract

Optimization Direct Compression’s Co-Processed Excipient Microcrystalline Cellulose PH 102 and Povidone® K 30

Abstract: 16,22 ± 0,39 % and 7,61 ± 0,12 kg, respectively

Cited by 5 publications

References 14 publications

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

Untitled

Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets

Contact Info

Product

Resources

About