Optimization in interstitial plasmonic photothermal therapy for treatment planning

Kannadorai, Ravi Kumar; Liu, Quan

doi:10.1118/1.4810935

Cited by 37 publications

(30 citation statements)

References 53 publications

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“…Several attempts were made to solve the equation analytically using the Green's function method [79]. However, the equation is mostly solved numerically using the finite difference method [80], the finite element method [81], the finite volume method [82] or the boundary element method [83]. To overcome the issue of parameter uncertainties in the PBTE, Fahrenholtz et al [84] described an approach that used inverse problems on patient MRTI data to train the PBTE parameter values.…”

Section: Bio-heat Transfermentioning

confidence: 99%

“…The optimisation of PTT via simulations was proposed in several studies [81,89]. In [81], an optimisation algorithm determining optimal gold nanoparticle concentration was proposed.…”

Section: Modelling Gold-nanoparticle-mediated Photo-thermal Ablationmentioning

confidence: 99%

“…The optimisation of PTT via simulations was proposed in several studies [81,89]. In [81], an optimisation algorithm determining optimal gold nanoparticle concentration was proposed. Additionally, new strategies that increased the efficacy of PTT were numerically analysed, such as the multisource model [90], or the indirect heating strategy [91].…”

Section: Modelling Gold-nanoparticle-mediated Photo-thermal Ablationmentioning

confidence: 99%

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Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles

Měsíček

Kuča

2018

International Journal of Hyperthermia

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The optimal light dose, heat generation, consequent heat spread and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy. The processes that occur in the treatments based on light propagation inside biological tissues and the subsequent temperature distributions are considered first, followed by evaluation of the thermal damage. The fundamental ideas underlying the presented methods are described in addition to their applications in photo-thermal therapy and its effects. The descriptions of extensively used tools for the characterisation of nanoparticles across multiple research fields are also presented for estimating the electromagnetic properties of gold nanoparticles (e.g. discrete dipole approximations, finite-difference time-domain simulations), the Monte Carlo model of light propagation in biological tissues, and the Pennes' bio-heat equation. In addition, the Arrhenius damage evaluation and the cumulative effective minutes normalisation methods are described. Finally, recent in vivo and in vitro results from the rapidly growing field of nanomedicine are presented.

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Section: Bio-heat Transfermentioning

confidence: 99%

“…The optimisation of PTT via simulations was proposed in several studies [81,89]. In [81], an optimisation algorithm determining optimal gold nanoparticle concentration was proposed.…”

Section: Modelling Gold-nanoparticle-mediated Photo-thermal Ablationmentioning

confidence: 99%

Section: Modelling Gold-nanoparticle-mediated Photo-thermal Ablationmentioning

confidence: 99%

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Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles

Měsíček

Kuča

2018

International Journal of Hyperthermia

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“…[7,8] Parasitic plasmonic absorption has long been recognized as an energy loss process in many plasmonic optical or optoelectronic nanodevices. [9][10][11][12][13] Although on the flipside it offers the opportunity to effectively heat nanostructures and thus be useful in applications such as photothermal therapy, [14] not until recently has this absorption event been revealed its feasibility for photonto-electricity harvesting. [15][16][17][18][19][20][21][22][23][24][25][26] Associated with nonradiative plasmonic decay, the highly energetic electrons, also known as 'hot electrons', can be captured before thermalization by constructing a metal-semiconductor (M-S) Schottky junction or metalinsulator-metal (MIM) configuration.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Photoelectric and Photothermal Responses on Silicon Platform by Plasmonic Absorber and Omni‐Schottky Junction

Wen

Chen

Liu

et al. 2017

Laser & Photonics Reviews

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Recent progresses in plasmon-induced hot electrons open up the possibility to achieve photon harvesting effiiencies beyond the fundamental limit imposed by band-to-band transitions in semiconductors. To obtain high efficiency, both the optical absorption and electron emission/collection are crucial factors that need to be addressed in the design of hot electron devices. Here, we demonstrate a photoresponse as high as 3.3mA/W at 1500nm on a silicon platform using a plasmonic absorber (PA) and an omni-Schottky junction integrated photodetector, reverse biased at 5V and illuminated with 10mW. The PA fabricated on silicon consists of a monolayer of random Au nanoparticles (NPs), a wide-band gap semiconductor (TiO2) and an optically thick Au electrode, resulting in broadband near-infrared (NIR) absorption and efficient hot-electron transfer via an all-around Schottky emission path. Time and spectral photoresponse measurements reveal that when the embedded NPs absorb the indicent radiation they act as local heating sources and transfer their energy to electricity via the photothermal mechanism, which until now has not been adequately assessed or rigorously differentiated from the photoelectric process in plasmon-mediated photon harvesting nano-systems

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“…Therefore, there is an advantage to incorporate effectively absorbing nanopar-ticles into the PPTT. For example, there are different theoretical and experimental approaches to optimize absorbing properties of Au spheres [48] or Au nanorods [38,49]. However, in our paper, we propose to utilize ideally absorbing two-and threelayered spherical nanoparticles for application with the PPTT method.…”

Section: Introductionmentioning

confidence: 99%

New ideally absorbing Au plasmonic nanostructures for biomedical applications

Zakomirnyi

Rasskazov

Карпов

et al. 2017

Journal of Quantitative Spectroscopy and Radiative Transfer

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In this paper a new set of plasmonic nanostructures operating at the conditions of an ideal absorption [1] was proposed for novel biomedical applications. We consider spherical x/Au nanoshells and Au/x/Au nanomatryoshkas, where 'x' changes from conventional Si and SiO 2 to alternative plasmonic materials [2], such as zinc oxide doped with aluminum, gallium and indium tin oxide. The absorption peak of proposed nanostructures lies within 700-1100nm wavelength region and corresponds to the maximal optical transparency of hemoglobin and melanin as well as to the radiation frequency of available pulsed medical lasers. It was shown that the ideal absorption takes place in a given wavelength region for Au coatings with thickness less than 12nm. In this case finite quantum size effects for metallic nanoshells play significant role. The mathematical model for the search of the ideal absorption conditions was modified by taking into account the finite quantum size effects.

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Optimization in interstitial plasmonic photothermal therapy for treatment planning

Cited by 37 publications

References 53 publications

Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles

Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles

Enhanced Photoelectric and Photothermal Responses on Silicon Platform by Plasmonic Absorber and Omni‐Schottky Junction

New ideally absorbing Au plasmonic nanostructures for biomedical applications

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