Optimization of 3D MP-RAGE for neonatal brain imaging at 3.0 T

Williams, Lori-Anne; DeVito, Timothy J.; Winter, Jeff; Orr, Timothy N.; Thompson, Robert T.; Gelman, Neil

doi:10.1016/j.mri.2007.01.119

Cited by 21 publications

(34 citation statements)

References 26 publications

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“…1 (Mugler and Brookeman, 1990). TI and segment delay (TD), duration to the next inversion-recovery pulse, are major parameters affected to strong T 1 contrast and signal intensity, respectively, and should be optimize because the signal intensity and contrast are different with tissue relaxation time of the animal species and the strength of using magnetic field used (Bock et al, 2009a;Deichmann et al, 2000;Williams et al, 2007).…”

Section: Numerical Simulation Of Signal Intensity and Contrastmentioning

confidence: 99%

Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

et al. 2011

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Section: Numerical Simulation Of Signal Intensity and Contrastmentioning

confidence: 99%

Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

et al. 2011

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“…The development of MR-compatible incubators and dedicated neonatal imaging coils has further enabled safe and fast acquisition of high-resolution anatomical and functional imaging of the neonatal brain with greater signal-to-noise ratio (SNR) [12]. However, image contrast and signal intensity changes occurring during the first year of life necessitate careful optimization of the experimental parameters used in neonatal MRI [13][14][15][16][17][18]. In neonates, image contrast is inverted relative to adults [19][20][21][22], as relaxation times of white matter (WM) are longer than those of gray matter (GM) [15,23].…”

Section: Introductionmentioning

confidence: 99%

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

et al. 2010

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Background T1-and T 2 -W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable. Objective To determine whether high-resolution T1-and T 2 -W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value. Materials and methods Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1-and T 2 -W highresolution sequences were optimized in terms of signal-tonoise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences. Results No differences were found between conventional and high-resolution T 1 -W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T 2 -W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T 2 -W images. Conclusion High-resolution T1-and T 2 -W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.R. Nossin-Manor (*)

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“…In (9)(10)(11), the calculation of longitudinal magnetization saturation during the RF pulse train for optimizing MP-RAGE sequences for brain images was based on the assumption of ideal RF spoiling. While the MP-RAGE sequences for neonatal brain imaging in (12) employed a previously proposed spoiling scheme (13) to further eliminate the transverse magnetization, a similar calculation was also adopted to obtain theoretical contrast for optimization of MP-RAGE sequences of neonatal brain imaging.…”

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confidence: 99%

Optimized inversion‐prepared gradient echo imaging

Kir

McMillan

2012

Magnetic Resonance Imaging

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Purpose: To implement a method using an extended phase graph (EPG)-based simulation to optimize inversion-prepared gradient echo sequences with respect to signal and contrast within the shortest acquisition time.Materials and Methods: A critical issue in rapid gradient-echo imaging is the effect of residual transverse magnetization between consecutive data acquisition windows. Various spoiling schemes have been proposed to mitigate this problem, and while spoiling is often considered to be perfect, imaging can be more truthfully described using the EPG. An EPG-based simulation is used to analyze and predict the image signal and contrast to serve as a basis for sequence optimization.Results: Fourteen biological phantom experiments and five brain imaging experiments on each of five healthy volunteers was performed to validate and verify the accuracy of the EPG-based simulation. In addition, two experiments on an in-cranial cadaver brain were performed to show the ability of the proposed method for improving overall image quality. Conclusion:From the experiment results, it is demonstrated that optimization of 3D magnetization-prepared rapid gradient-echo imaging sequences can be performed with an EPG-based simulation to manipulate the sequence parameters for generating images with highly specific signal and contrast characteristics for quantitative T1-weighted human brain imaging.

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Optimization of 3D MP-RAGE for neonatal brain imaging at 3.0 T

Cited by 21 publications

References 26 publications

Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

Optimized inversion‐prepared gradient echo imaging

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