2023
DOI: 10.1101/2023.08.31.555767
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Optimization of a Cardiomyocyte Model Illuminates Role of Increased INaLin Repolarization Reserve

Kristin E Fullerton,
Alexander P. Clark,
Trine Krogh-Madsen
et al.

Abstract: Cardiac ion currents may compensate for each other when one is compromised by a congenital or drug-induced defect. Such redundancy contributes to a robust repolarization reserve that can prevent the development of lethal arrhythmias. Most efforts made to describe this phenomenon have quantified contributions by individual ion currents. However, it is important to understand the interplay between all major ion channel conductances, as repolarization reserve is dependent on the balance between all ion currents i… Show more

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