Optimization of a cell surface vimentin binding peptoid to extract antagonist effect on lung cancer cells

Zhang, Haowen; Udugamasooriya, D. Gomika

doi:10.1016/j.bioorg.2022.106113

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…There are thoracic CT scans in the Lung Image Database Consortium image collection (LIDC-IDRI) [23] that have been annotated with lesions for the diagnosis and screening of lung cancer that may be used for diagnostic and screening purposes. Online access to one of the world's top resources for assistance with computer-assisted diagnostic (CAD) techniques for lung cancer detection and diagnosis is accessible to anybody in the globe.…”

Section: Image Dataset Descriptionmentioning

confidence: 99%

Lung Cancer Classification with Improvised Three Parameter Logistic Type Distribution Model

Joshua¹,

Bhattacharyya²,

Rao³

et al. 2023

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Lung cancer is the leading cause of mortality worldwide, affecting both men and women equally. Identifying and treating these nodules when they are still tiny may increase their chances of survival significantly. However, due to the large amount of data generated by this CT scanner, manual segmentation and interpretation takes a long time and is quite challenging to do on your own. When a radiologist focuses on the patient's body, it increases the strain on the radiologist, and the likelihood of missing pathological information, such as abnormalities, is also increased. One of the primary objectives of this project is to develop computer-assisted diagnosis and detection of lung cancer. It also intends to make it easier for radiologists to identify and diagnose lung cancer more rapidly and accurately. Based on a unique picture feature, the proposed strategy k into consideration the spatial interaction of voxels that were next to one another. Using the U-NET+Three parameter logistic distribution-based technique, we were able to replicate the situation. According to the researchers, the proposed technique method DSC of 97.3%, a sensitivity of 96.5%, and a specificity of 94.1% when tested on the LuNa-16 dataset. At long last, this research investigates how diverse lung segmentation, juxta pleural nodule inclusion, and pulmonary nodule segmentation approaches may be applied to create CAD systems. Other objectives include making it possible to conduct research into lung segmentation and automated pulmonary nodule segmentation while also improving the power and effectiveness of computer-assisted diagnosis of lung cancer, which relies on correct pulmonary nodule segmentation to be successful.

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Section: Image Dataset Descriptionmentioning

confidence: 99%

Lung Cancer Classification with Improvised Three Parameter Logistic Type Distribution Model

Joshua¹,

Bhattacharyya²,

Rao³

et al. 2023

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“…An attractive strategy to develop high affinity ligands for these proteins is to create homodimers and thus take advantage of avidity effects to buttress the intrinsic affinity of the monomeric ligand. This strategy has been applied successfully to the development of high affinity agonists or antagonists of the Vascular Endothelial Growth Factor Receptors (VEGFRs), [1] HSP90, [2] vimentin, [1b] XIAP, [3] PSD‐95, [4] EphA2, [5] 14‐3‐3sigma, [6] b‐tryptase, [7] various GPCRs, [8] and many other proteins. While several methods are available to link together two protein ligands to create a dimer, most of these processes require the synthesis of two different derivatives of the monomeric ligand, for example alkyne‐ and azide‐functionalized molecules [4b] if one wishes to use a copper‐catalyzed Huisgen cycloaddition [9] .…”

Section: Introductionmentioning

confidence: 99%

2‐Pyridone Formation: An Efficient Method for the Solid‐Phase Synthesis of Homodimers

Abboud,

Kodadek

2023

Chemistry A European J

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This study presents an efficient method for on‐resin dimer generation through self‐condensation of 3,3‐dimethoxypropionic acid‐modified molecules, resulting in 2‐pyridones. The approach demonstrated remarkable versatility by producing homodimers of peptides, peptoids, and non‐peptidic ligands. Its ease of application, broad utility, and mild reaction conditions not only hold significance for peptide and peptoid research but also offer potential for the on‐resin development of a wide range of bivalent ligands.

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Recent advances in anticancer peptoids

Zhu

Chen

Liu

et al. 2023

Bioorganic Chemistry

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Optimization of a cell surface vimentin binding peptoid to extract antagonist effect on lung cancer cells

Cited by 5 publications

References 33 publications

Lung Cancer Classification with Improvised Three Parameter Logistic Type Distribution Model

Lung Cancer Classification with Improvised Three Parameter Logistic Type Distribution Model

2‐Pyridone Formation: An Efficient Method for the Solid‐Phase Synthesis of Homodimers

Recent advances in anticancer peptoids

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