Optimization of a Diamond Nitrogen Vacancy Centre Magnetometer for Sensing of Biological Signals

Webb, James L.; Troise, Luca; Hansen, Nikolaj Winther; Achard, Jocelyn; Brinza, Ovidiu; Staacke, Robert; Kieschnick, Michael; Meijer, Jan; Perrier, Jean-Françóis; Berg-Sørensen, Kirstine; Huck, Alexander; Andersen, Ulrik L.

doi:10.3389/fphy.2020.522536

Cited by 34 publications

(22 citation statements)

References 48 publications

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“…Without magnetic shielding, it was necessary to remove a substantial amount of magnetic noise from our sensor readout, including stationary mains noise at harmonics of 50Hz and non-stationary noise from building pumps and compressors. In our previous work, we demonstrated filtering using windowed notch filtering 56 . However this noise removal was suboptimal, due to the use of serially generated fixed frequency windows and a single global threshold value to identify noise peaks, constraints imposed by computational time.…”

Section: E Filtering By Spectral Whiteningmentioning

confidence: 99%

Laser stimulation of muscle activity with simultaneous detection using a diamond colour centre biosensor

Troise¹,

Hansen²,

Olsson³

et al. 2021

Preprint

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The detection of physiological activity at the microscopic level is key for understanding the function of biosystems and relating this to physical structure.Current sensing methods often rely on invasive probes to stimulate and detect activity, bearing the risk of inducing damage in the target system. In recent years, a new type of biosensor based on color centers in diamond offers the possibility to passively, noninvasively sense and image living biological systems. Here, we use such a sensor for the in-vitro recording of the local magnetic field generated by tightly focused, high intensity pulsed laser optogenetic neuromuscular stimulation of the extensor digitorum longus muscles. Recordings captured a compound action potential response and a slow signal component which we seek to explain using a detailed model of the biological system. We show that our sensor is capable of recording localized neuromuscular activity from the laser stimulation site without photovoltaic or fluorescence artifacts associated with alternative techniques. Our work represents an important step towards selective induction of localized neurobiological activity while performing passive sensing and imaging with diamond sensors, motivating further research into mapping of neural activity and intra-cellular processes.

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Section: E Filtering By Spectral Whiteningmentioning

confidence: 99%

Laser stimulation of muscle activity with simultaneous detection using a diamond colour centre biosensor

Troise¹,

Hansen²,

Olsson³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Microwave and optical heating In spin-based thermometry, microwave irradiation can cause a change in the temperature during the measurement process because of microwave-induced water heating, resulting in an ODMR shift [197][198][199]. The excitation microwave power depends on the antenna structure and coupling efficiency between the antenna and delivery waveguide.…”

Section: Sensing Selectivity and Artefactsmentioning

confidence: 99%

Diamond quantum thermometry: From foundations to applications

Fujiwara,

Shikano

2021

Preprint

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Diamond quantum thermometry exploits the optical and electrical spin properties of colour defect centres in diamonds and, acts as a quantum sensing method exhibiting ultrahigh precision and robustness. Compared to the existing luminescent nanothermometry techniques, a diamond quantum thermometer can be operated over a wide temperature range and a sensor spatial scale ranging from nanometres to micrometres. Further, diamond quantum thermometry is employed in several application, including electronics and biology, to explore these fields with nanoscale temperature measurements. This review covers the operational principles of diamond quantum thermometry for spin-based and alloptical methods, material development of diamonds with a focus on thermometry, and examples of applications in electrical and biological systems with demandbased technological requirements.

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“…40,41 Here, the readout is based on the optical signal of NV centers. Recent focus on the use of NV in diamond as a magnetic sensor 42 designed for biological living systems has reached, even in DC magnetometry, the sensitivity of 100 pT∕ ffiffiffiffiffiffi Hz p , 43 and, by using a lock-in-based technique to read out optically the NV spin , a sensitivity of 68 nT∕ ffiffiffiffiffiffi Hz p within the (sub)cellular scale has been achieved. 44 As such, the quantum properties of CCs can be used or combined with traditional SRM that does not rely on the quantum nature of the nanoprobes but on their nonlinear optical properties or on their nonstationary fluorescence, which makes them discernible from one to another.…”

Section: Introductionmentioning

confidence: 99%

Color centers in wide-bandgap semiconductors for subdiffraction imaging: a review

Castelletto

Boretti

2021

Adv. Photon.

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Solid-state atomic-sized color centers in wide-band-gap semiconductors, such as diamond, silicon carbide, and hexagonal boron nitride, are important platforms for quantum technologies, specifically for single-photon sources and quantum sensing. One of the emerging applications of these quantum emitters is subdiffraction imaging. This capability is provided by the specific photophysical properties of color centers, such as high dipole moments, photostability, and a variety of spectral ranges of the emitters with associated optical and microwave control of their quantum states. We review applications of color centers in traditional super-resolution microscopy and quantum imaging methods, and compare relative performance. The current state and perspectives of their applications in biomedical, chemistry, and material science imaging are outlined.

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Optimization of a Diamond Nitrogen Vacancy Centre Magnetometer for Sensing of Biological Signals

Cited by 34 publications

References 48 publications

Laser stimulation of muscle activity with simultaneous detection using a diamond colour centre biosensor

Laser stimulation of muscle activity with simultaneous detection using a diamond colour centre biosensor

Diamond quantum thermometry: From foundations to applications

Color centers in wide-bandgap semiconductors for subdiffraction imaging: a review

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