“…The factory layout problem concerns the spatial positioning of work stations, machines, tools, and/or functional areas in order to increase the efficiency of the production flow while respecting the application specific constraints, e.g., building boundaries and pathway dimensions. There is a significant amount work on optimizing the layout by simulation of production schedules on a virtual digital factory environment on simulated data (see, e.g., Centobelli et al [49], Lee et al [135], Kanduč and Rodič [121], Herr et al [114]), which can be partly based on real-time data and/or movement analytics on the current factory setup. Different objectives or combination of have been studied, e.g., minimum travel time/distance (see, e.g., Dzeng et al [84], Kanduč and Rodič [121], Herr et al [114]) and minimum production lead time (see, e.g., Centobelli et al [49]).…”