Optimization of a hydroformulation process in a thermomorphic solvent system using a commercial steady-state process simulator and a memetic algorithm

Iterative Process Design with Surrogate‐Assisted Global Flowsheet Optimization

“…Most process simulators offer options to resolve a constraint violation, e.g., by design specifications or by using internal solvers. Exploiting these options can lead to significant performance improvements [9], but they are vendor-specific. Our goal here is to improve the handling of design constraints independent from a specific simulator so that the framework can be used with any flowsheet simulation software.…”

“…Also, an extension for multi-objective optimization [8] was developed. Janus et al [9] found that the use of derivativefree optimization methods for local refinement is not worth the effort in comparison to only use an evolution strategy during the course of an optimization. They also integrated an interface to internal local optimizers of the process simulators and used it for constraint satisfaction.…”