Optimization of a &lt;i&gt;γ&lt;/i&gt;-aminobutyric Acid (GABA) Enrichment Process for Hokkaido White Rice and the Effects of GABA-enriched White Rice on Stress Relief in Humans

Shin'ichi, Yoshida; Haramoto, Masafumi; Fukuda, Teruyo; Mizuno, Hidenori; Tanaka, Aiko; Nishimura, Mie; Nishihira, Jun

doi:10.3136/nskkk.62.95

Cited by 12 publications

(10 citation statements)

References 8 publications

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“…Two 8-week intervention studies examined the effect of consuming GABA-enriched rice on sleep in healthy individuals. Yoshida et al ( 2015 ), studying healthy middle aged individuals with poor sleep, found a trend for improved feelings upon awakening in GABA rice (16.8 mg GABA in 150 g GABA rice/day) (vs. white rice−4.1 mg GABA in 150 g white rice/day) group at the 4th week of intervention and after 2 weeks of the intervention (i.e., at the 10th week). They did not find an effect of GABA rice on VAS sleepiness score.…”

Section: Resultsmentioning

confidence: 99%

“…The effects of GABA on other HRV parameters and subjective stress were not significant. Another study by Yoshida et al (2015) showed that 8 weeks consumption of GABA rice (16.8 mg GABA in 150 g GABA rice/day) improved subjective calmness and worry scores midway through the study at the 4th week of the treatment compared to white rice (4.1 mg GABA in 150 g GABA rice/day), however, these effects were not maintained. They also reported trends for reduced blood cortisol and increased adiponectin levels in GABA rice (vs. white rice) condition at the 8th week of the treatment.…”

Section: The Effect Of Gaba Consumption On Stressmentioning

confidence: 97%

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Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review

et al. 2020

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Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. Fourteen studies met the criteria and were included in the systematic review. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake.

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Section: Resultsmentioning

confidence: 99%

Section: The Effect Of Gaba Consumption On Stressmentioning

confidence: 97%

Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review

et al. 2020

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“…However, transgenic rice cannot be sold in Japan. In E-mail: kkawaka@med.shimane-u.ac.jp addition, GABA-abundant sprouted brown rice is sold and a 'grain GABA-enriching device' to increase the GABA content of polished rice has been developed (6,7). In this study, the functionality of 'GABA-enriched brown rice' (GEBR) containing a high concentration of GABA was investigated with regard to its influence on BP by ad libitum ingestion in spontaneously hypertensive rats (SHR).…”

mentioning

confidence: 99%

Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats

Kawakami

Yamada

et al. 2018

Journal of Nutritional Science and Vitaminology

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'Haiibuki' is a giant embryo rice cultivar that contains abundant γ-aminobutyric acid (GABA) compared with conventional rice cultivars. Here, we performed a functional evaluation of 'GABA-enriched brown rice' (GEBR) prepared by modifying the 'Haiibuki' cultivar to contain more GABA. Study 1: Spontaneously hypertensive rats were divided into three groups [control (cornstarch), normal brown rice, and GEBR] and fed an orally administered diet for 4 wk. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group as compared with the other groups. Study 2: Rats were divided into two groups and fed ad libitum for 12 wk. The two groups were control (commercial feed with 5% cornstarch) and GEBR (commercial feed with 5% GEBR). Body weight, blood pressure, food consumption, and water intake were measured during the study period, and blood chemistry was analyzed after the study. Plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) and urinary isoprostane were measured 12 and 10 wk after the start of the study, respectively. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group. The 8-OHdG and isoprostane levels were significantly lower in the GEBR group than in the control group, demonstrating an oxidative stress-reducing effect. Therefore, GEBR exhibited a blood pressure elevation-inhibitory effect under the conditions of this study. The antioxidative action may occur secondarily to the antihypertensive action of GABA, suggesting that the long-term ad libitum ingestion of GEBR prevents hypertension. A reduction in oxidative stress could reduce the chances of complications in cardiovascular diseases.

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“…Four strains of LAB-namely N8, N9, N10, and N30-were cultured in an MRS liquid medium in a 96-well microplate at different NaCl concentrations (0, 1, 2, and 3% (w/v)), pH levels (2-9) and incubation temperatures (10,15,20,25,30, and 35 • C). After incubation at 28 • C for 72 h, the optical density (OD) at 600 nm was measured in a spectrophotometer (V-530, JASCO, Tokyo, Japan) to evaluate the growth.…”

Section: Effect Of Nacl Ph and Temperatures On The Growth Of Gaba-prmentioning

confidence: 99%

“…Therefore, LAB is widely applied as starter cultures in fermented foods, probiotics, and/or biopreservative agents [16][17][18]. Additionally, it is known that some LAB can produce GABA [19][20][21]. It is well known that GABA is a functional non-protein amino acid that is synthesized from glutamate via decarboxylation due to an enzymatic reaction or through the degradation of polyamine [22].…”

Section: Introductionmentioning

confidence: 99%

Production of Anserine-Rich Fish Sauce from Giant Masu Salmon, Oncorhynchus masou masou and γ-Aminobutyric Acid (GABA)-Enrichment by Lactobacillus plantarum Strain N10

et al. 2019

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Previously, we developed a novel production technique for giant masu salmon (GMS). This study aimed to develop a fish sauce from GMS to explore ways to efficiently utilize the salmon and to enrich the fish sauce with γ-aminobutyric acid (GABA) by microbial fermentation. The minced bodies of GMS were autolyzed by endogenous protease at 55 °C and 60 °C. During autolysis, the changes in total free amino acids and protein size was monitored by LC-MS and SDS-PAGE analysis, respectively. After 96 h, fish sauce was prepared by heating, and the amino acid composition was analyzed by LC-MS. To enrich the fish sauce with GABA, Lactobacillus plantarum strain N10 was added and incubated at 28 °C for 48 h. The total free amino acids content significantly increased for 96 h. SDS-PAGE analysis showed that major bands at 200 kDa and 48 kDa detected at 0 h gradually disappeared over time. The ratio of anserine to total amino acids in the fish sauce was approximately 36%. The concentration of GABA in the fish sauce significantly increased through the addition of strain N10. Thus, anserine-rich fish sauce could be quickly produced from GMS, and the fish sauce was enriched with GABA by microbial fermentation.

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Optimization of a <i>γ</i>-aminobutyric Acid (GABA) Enrichment Process for Hokkaido White Rice and the Effects of GABA-enriched White Rice on Stress Relief in Humans

Cited by 12 publications

References 8 publications

Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review

Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review

Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats

Production of Anserine-Rich Fish Sauce from Giant Masu Salmon, Oncorhynchus masou masou and γ-Aminobutyric Acid (GABA)-Enrichment by Lactobacillus plantarum Strain N10

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