Optimization of a Screw Centrifugal Blood Pump Based on Random Forest and Multi-Objective Gray Wolf Optimization Algorithm

Abstract

The centrifugal blood pump is a commonly used ventricular assist device. It can replace part of the heart function, pumping blood throughout the body in order to maintain normal function. However, the high shear stress caused by the impeller rotating at high speeds can lead to hemolysis and, as a consequence, to stroke and other syndromes. Therefore, reducing the hemolysis level while ensuring adequate pressure generation is key to the optimization of centrifugal blood pumps. In this study, a screw centrifugal blood pump was used as the research object. In addition, pressure generation and the hemolysis level were optimized simultaneously using a coupled algorithm composed of random forest (RF) and multi-objective gray wolf optimization (MOGWO). After verifying the prediction accuracy of the algorithm, three optimized models were selected and compared with the baseline model in terms of pressure cloud, 2D streamline, SSS distribution, HI distribution, and vortex distribution. Finally, via a comprehensive evaluation, the optimized model was selected as the final optimization design, in which the pressure generation increased by 24% and the hemolysis value decreased by 48%.

An effective approach for adaptive operator selection and comparison for PSO algorithm

“…Recent studies have shown that metaheuristic algorithms perform well in solving high-dimensional optimization problems. Particle Swarm Optimization (PSO) [1], Gray Wolf Optimizer Algorithm [2], Genetic Algorithm [3], Differential Evolution Algorithm [4], Ant Colony Algorithm [5], Artificial Bee Colony Algorithm [6], Simulated Annealing Algorithm [7] are the most known and widely used stateof-the-art metaheuristic algorithms. PSO algorithm seems to be preferred more than other algorithms due to its ease of use, ability to search for the global optimum and higher convergence rate [8][9].…”

Numerical Analysis of a Novel Rotating Piston Blood Pump Based on CFD

“…According to the theory of fluid mechanics, the shear stress between a solid and a liquid is greater than that between two liquids under the same conditions [6]. Therefore, the maximum shear stress is usually distributed on the wall surface where the blood comes into contact with the pump body.…”