Optimization of an in vitro method to measure the bioaccessibility of polybrominated diphenyl ethers in dust using response surface methodology

Yu, Yingxin; Pang, Yu-Ping; Zhang, Xinyu; Li, Chen; Yu, Zhiqiang; Fu, Jiamo

doi:10.1016/s1001-0742(10)60571-2

Cited by 18 publications

(4 citation statements)

References 35 publications

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“…They are blended physically withrather than chemically bound to -polymeric materials, which likely lead them to migrate into the environment (WHO, 1997;USEPA, 2010Alaee et al, 2003. PBDEs are persistent and bioaccumulative toxicants, with available information suggesting that they affect negatively the nervous system, the liver and the thyroid system (NICNAS, 2007;USEPA, 2008;Shaw et al, 2009;Noyes et al, 2010;Yu et al, 2011;Johnson et al, 2013;Yang et al, 2014;Zhang et al, 2014;Fang & Stapleton, 2014). Hence, their manufacture and new use is now banned or severely restricted in many jurisdictions, and they are listedor in the case of the Deca-BDE product nominated for listing -under the Stockholm Convention on Persistent Organic Pollutants (POPs) (UNEP, 2008;2013a;.…”

Section: Introductionmentioning

confidence: 99%

Distribution pattern of legacy and “novel” brominated flame retardants in different particle size fractions of indoor dust in Birmingham, United Kingdom

Al-Omran

Harrad

2016

Chemosphere

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This study investigates the particle size distribution of eight polybrominated diphenyl ethers (PBDEs) and five "novel" brominated flame retardants (NBFRs) in settled house dust. Elevated surface dust (ESD) and floor dust (FD) were collected from 5 homes in Birmingham, UK, yielding a total of 10 samples. Each sample was fractionated into three different particle sizes: 125-250 μm (P1), 63-125 μm (P2) and 25-63 μm (P3). Non-fractionated bulk dust samples (BD) were also analysed. BDE-209 predominated, comprising an average 74.3%, 77.3%, 69.2%, and 62.7% ΣBFRs of BD, P1, P2 and P3 respectively. Σ5NBFRs contributed 24.2%, 21.5%, 29.0% and 35.3% ΣBFRs, while Σ7tri-hepta-BDEs represented 1.5%, 1.2%, 1.7%, and 2.0% ΣBFRs. BEH-TEBP was the predominant NBFR contributing 76.9%, 75.1%, 83.1%, and 83.9% ΣNBFRs in BD, P1, P2 and P3 respectively; followed by DBDPE which contributed 20.1%, 21.9%, 14.1% and 13.9% ΣNBFRs. EH-TBB, BTBPE and PBEB were the least abundant NBFRs. Concentrations of Σ7tri-hepta-BDEs and BEH-TEBP in P3 exceeded significantly (P < 0.05) those in P2, with those in P2 exceeding significantly those in P1. In contrast, no significant differences were found between concentrations of BDE-209, EH-TBB, BTBPE, and DBDPE in different particle size fractions. Concentrations of Σ7tri-hepta-BDEs, BDE-209, and BEH-TEBP in ESD exceeded significantly those in FD (P < 0.05). Normalising BFR concentrations to organic carbon content, did not alter these findings. This suggests that differences in BFR concentrations between different particle size fractions are caused by variations in particle surface area to volume ratio, rather than by variations in organic carbon content.

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Section: Introductionmentioning

confidence: 99%

Distribution pattern of legacy and “novel” brominated flame retardants in different particle size fractions of indoor dust in Birmingham, United Kingdom

Al-Omran

Harrad

2016

Chemosphere

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“…Lower S/L ratios have shown saturation phenomena of the chemicals in the GI solutions (Van de Wiele et al, 2007) which may result in underestimated bioaccessibility values and S/L ratios between 1/150 and 1/250 have been suggested as optimum (Yu et al, 2011). 0.3 g of each dust was exposed in 50 mL of stomach solution at pH 2.5 which also contained food components and the samples were incubated for 1h at 37°C…”

Section: Incubation With Ce-pbetmentioning

confidence: 99%

Does the source migration pathway of HBCDs to household dust influence their bio-accessibility?

Garcia‐Alcega

Rauert

Harrad

et al. 2016

Science of The Total Environment

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A study was conducted to assess the human bioaccessibility of dust contaminated with hexabromocyclododecane (HBCD) via two migration pathways a) volatilisation with subsequent partitioning to dust particles, and b) abrasion of treated textile fibres directly to the dust. This was achieved using previously developed experimental chamber designs to generate dust samples contaminated with HBCDs emitted from a HBCD treated textile curtain. The generated dust samples were exposed to an in vitro colon extended physiologically based extraction test (CE-PBET). The bioaccessibility of the HBCDs which were incorporated within dust as a result of volatilisation from the curtain material with subsequent partitioning to dust was higher than in dusts contaminated with HBCDs via abrasion of the curtain (35% and 15% respectively). We propose this occurs due to a stronger binding of HBCDs to treated fabric fibres than that experienced following volatilisation and sorption of HBCDs to dust particles.

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“…Based on the previous study the conditions of PAHs extraction by UAE-DLLME-SFO were: 80µL of extractant volume, 0.8mL of dispersant volume, 0.54g of soil quality, 3% of salt effect, 3.1 min of ultrasonic time and 59kw of ultrasonic power, and the conditions were utilized for samples determination at different levels [15]. The linear range, relative coefficients and limit of detection were observed (Table 2).…”

Section: Linear Range and Limit Of Detectionmentioning

confidence: 99%

Ultrasonic-Assistant Dispersive Liquid-Liquid Microextraction Based on Solidification of Floating Organic Droplet Method for Quick Determination of Polycyclic Aromatic Hydrocarbons in Soils

Zhang

Jiang

Meng

et al. 2012

AMM

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An ultrasound-assisted dispersive liquid-liquid micro-extraction method based on solidification of floating organic drop (UAE/DLLME/SFO) was established for the determination of PAHs in soils. Dichloromethane was used as solvent for the analytes in the soil by ultrasonic assistant extraction (UAE), the solvent was purified and concentrated by silica gel column chromatography and nitrogen flowing concentrator, respectively. The recoveries of the method were in the range 46.22-101.86%, and the relative standard deviations (RSD) were 3.03-7.80%. The linear range was 0.02-0.4mg/kg（0.02-0.5mg/kg）, and the limit of detection (LOD) was 0.17-29.13µg/kg. The method was applied to the real soil samples around wells of an oilfield; the relative recoveries of the ANY, ANA, FLU, PHE, ANT, FLT, PYR, BaA were 47.12-116.96%, while the recoveries of NAP, CHR, BbF, BkF, BaP, DBA, BPE, IPY were 17.75-63.29%.

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Optimization of an in vitro method to measure the bioaccessibility of polybrominated diphenyl ethers in dust using response surface methodology

Cited by 18 publications

References 35 publications

Distribution pattern of legacy and “novel” brominated flame retardants in different particle size fractions of indoor dust in Birmingham, United Kingdom

Distribution pattern of legacy and “novel” brominated flame retardants in different particle size fractions of indoor dust in Birmingham, United Kingdom

Does the source migration pathway of HBCDs to household dust influence their bio-accessibility?

Ultrasonic-Assistant Dispersive Liquid-Liquid Microextraction Based on Solidification of Floating Organic Droplet Method for Quick Determination of Polycyclic Aromatic Hydrocarbons in Soils

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