Optimization of an Oral Magnetic Particle Formulation as a Gastrointestinal Contrast Agent for Magnetic Resonance Imaging

Rubin, Daniel L.; Muller, Holde H.; Young, Stuart W.; Hunke, William A.; Gorman, William G.

doi:10.1097/00004424-199401000-00017

Cited by 6 publications

(1 citation statement)

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“…The rapid clearance of these nanoparticles from the circulation was due to opsono-phagocytosis by macrophages of the mononuclear phagocyte system (MPS) [9,10]. Despite the rapid MPS uptake, such colloidal systems, generally named superparamagnetic iron oxides (SPIO) have become useful tools by oral or rectal administration route for the imaging of the gastrointestinal (GI) tract [11,12] and by IV injection for the diagnosis of tumors or metastasis in the liver [13,14] and the spleen [15]. Imaging of tumors is made possible by the lack of accumulation of the SPIO in the malignant tissue, because of the absence of macrophages in these areas, thus providing good contrast with the normal tissue in MRI.…”

Section: Ii1 Superparamagnetic Nanoparticles As Contrast Agents In mentioning

confidence: 99%

Metallic Colloid Nanotechnology, Applications in Diagnosis and Therapeutics

Sonvico

Dubernet²,

Colombo³

et al. 2005

CPD

157

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In recent years the fields of medicine and biology assist to an ever-growing innovation related to the development of nanotechnologies. In the pharmaceutical domain, for example, liposomes, polymer based micro and nanoparticles have been subjects of intense research and development during the last three decades. In this scenario metallic particles, which use was already suggested in the first half of the '80, are now experiencing a real renaissance. In the field of diagnosis, magnetic resonance imaging is one of the first and up to now the most developed application of metallic particles. But beside this application, a very new generation of biosensors based on the optical properties of colloidal gold and fluorescent nanocrystals, called quantum dots seems to be ready to be implemented in diagnosis and medical imaging. Concerning therapeutic applications, the potentialities of metal nanoparticles to help fulfilling the need of time and space controlled release of drugs has been intuited for a long time. Nowadays, magnetically guided carriers or thermal responsive matrices, in which drug release is triggered by the heating of metal nanoparticles, are effective examples of their application in drug delivery, while more recently efforts to develop metallic nanoobjects to be used as vectors of nucleic acids for vaccination and transfection have been multiplied. In the future, one of the most interesting challenges is certainly the use of metallic nanoparticles for an innovating, effective and selective physical treatment of solid tumors via targeted intracellular hyperthermia.

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Section: Ii1 Superparamagnetic Nanoparticles As Contrast Agents In mentioning

confidence: 99%

Metallic Colloid Nanotechnology, Applications in Diagnosis and Therapeutics

Sonvico

Dubernet²,

Colombo³

et al. 2005

CPD

157

View full text Add to dashboard Cite

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Radiopaques

Peng

2003

Burger's Medicinal Chemistry and Drug Discovery

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This review discusses radiopaques from research and development to application. Radiopaques attenuate X‐rays and may be either high atomic‐numbered materials or iodinated organic compounds. The latter may appear sometimes in liposomes or particulates. The theoretical and historical aspects, classification by structures, methods of synthesis, structure‐activity relationship, physical, chemical, and pharmacological properties, and related reactions, essential to the understanding of safety, tolerability, and efficacy of radiopaques in medical use, are included in the discussion.

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