A new control problem of roll-pitch seeker about the disturbance coupling is investigated in this work. Previous control strategies of roll-pitch seeker rarely considered the effects of the dynamic coupling disturbances from the missile angular motion, and because of the polar coordinate structure, the disturbance rejection strategies of yaw-pitch seeker cannot be utilized directly on roll-pitch seeker. Thus this article presents a new control strategy to improve the disturbance rejection ability of roll-pitch seeker. To analyze the disturbance coupling problem, the roll-pitch seeker model is derived with consideration of the missile body angular motion and torque disturbances. The motion equation of roll-pitch seeker shows that part of the dynamic coupling disturbance can be eliminated by certain choices of inertial parameters. The rest of disturbance is reduced by the stabilization loops using a differentiator-based disturbance compensation controller. Particularly, a missile body angular acceleration estimation method is designed for the compensator based on an adaptive differentiator. In addition, comparisons with other control strategies are carried out via numerical simulations, and the results confirm the effectiveness of the proposed method.