Optimization of Ball Ratio in Planetary Ballmill in Nimodipine-poloxamer 188 Nanoparticle Formulation Process

Abstract

Nimodipine is a drug that belongs to the class II biopharmaceutical classification system which has low solubility with high permeability. The ball mill ratio is a factor that affects the results of milling using a planetary ballmill. This study aims to see the optimal ball ratio in the milling process with a planetary ball mill in the physicochemical characterization of nimodipine-poloxamer 188 nanoparticles and their dissolution rate. Milling in a planetary ball mill was carried out using zirconium balls at a ratio of 20%, 25%, and 30% to the volume of the vessel respectively for 1, 2, and 3 nanoparticles. The characterization of nanoparticles includes PSA with the results showing a reduction in particle size, XRD there is a decrease in peak intensity, DSC there is a decrease in melting point, FT-IR doesn’t change the wave number, SEM shows morphologically a change in shape, TLC indicates no chemical interaction, in the assay, the percentage of nimodipine and nanoparticles 1,2,3 was respectively 98.91%, 99.85%, 100.73%, 99.31%. the solubility test of nimodipine and nanoparticles 1,2,3, respectively 0.3390 g/ml, 19.8698 g/ml, 6.0673 g/ml, 8.4405 g/ml, and the dissolution test showed an increase in the 60th minute of nanoparticles 1,2 and 3 respectively 61,5841%, 52,3159%, 56,6027% compared with 23.3978% pure nimodipine. The results of the ANOVA test of solubility and dissolution rate showed that there was a significant difference between nimodipine-poloxamer 188 nanoparticles and pure nimodipine.