With the removal of indoor pollutants and the assurance of air quality emerging as critical research topics, the optimization of the internal environment in offices, where people stay for extended periods, is essential for controlling the spread of infectious respiratory particles. Frequent movements of personnel and the operation of doors and windows within offices significantly impact the mechanisms of droplet transmission, warranting further investigation. This study employs computational fluid dynamics simulations to explore the droplet dispersion characteristics and pollutant removal efficiency of the simplified model of perforated plate ventilation system (PPVS) (the diameter of the air supply openings has been reasonably simplified and uniformly set to 0.02 m) in office settings, as well as the impact of dynamic door operation scenarios on droplet spread and concentrations in breathing zones. To optimize the ventilation system's pollutant removal efficiency, airflow velocities (2.86, 3.18, and 5.00 m/s) are varied, with simulations conducted at the optimal velocity of 3.18 m/s. The effects of continuous door operations, door‐opening directions (towards the office and towards the isolation room), and opening speeds (π/4, π/6, π/8, and π/10 rad/s) are also examined, revealing significant impacts on droplet spread. Results indicate that PPVS effectively reduces indoor pollutant concentrations at all tested airflow velocities, with the optimal speed identified as 3.18 m/s. Additionally, door‐opening direction and speed can significantly influence droplet spread. Opening doors towards isolation rooms at smaller angles (less than 30°) effectively reduces droplet concentrations in personnel breathing zones, thereby mitigating the risk of droplet transmission. Faster door‐opening speeds also contribute to lower droplet concentrations in these zones. This innovative study explores the impacts of PPVS and dynamic door operation dynamics on droplet transmission during respiratory disease outbreaks, providing valuable theoretical insights and technical support for disease prevention and indoor air quality improvement.