Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Ghasemian, Elham; Rezaeian, Behnaz; Alaei, Samaneh; Vatanara, Alireza; Ramezani, Vahid

doi:10.15171/ps.2015.28

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Drug solubility in water is a factor that affects the release rates and the bioavailability of the drug. [75] Water-insoluble drugs can be challenging to deliver due to their slow-release rate in aqueous media and low bioavailability. [76] Jung et al showed that the solubility of itraconazole (ITA) is enhanced through incorporation into Laponite.…”

Section: Drug Solubilitymentioning

confidence: 99%

Laponite‐Based Nanomaterials for Drug Delivery

Kiaee

Dimitrakakis

Sharifzadeh

et al. 2022

Adv Healthcare Materials

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Laponite is a clay-based material composed of synthetic disk-shaped crystalline nanoparticles with highly ionic, large surface area. These characteristics enable the intercalation and dissolution of biomolecules in Laponite-based drug delivery systems. Furthermore, Laponite's innate physicochemical properties and architecture enable the development of tunable pH-responsive drug delivery systems. Laponite's coagulation capacity and cation exchangeability determine its exchange capabilities, drug encapsulation efficiency, and release profile. These parameters are exploited to design highly controlled and efficacious drug delivery platforms for sustained drug release. In this review, they provide an overview of how to design efficient delivery of therapeutics by leveraging the properties and specific interactions of various Laponite-polymer composites and drug moieties.

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Section: Drug Solubilitymentioning

confidence: 99%

Laponite‐Based Nanomaterials for Drug Delivery

Kiaee

Dimitrakakis

Sharifzadeh

et al. 2022

Adv Healthcare Materials

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“…Nanotechnology is probably going to roll out a major improvement in our lives and well-being situation. 1,2 It is a standout amongst the most vital innovative work territory in the present time. Nanotechnology is a pertinent part of a more extensive territory of nanoscience which is one of the upcoming and very testing just as remunerating key research zone in the cutting edge logical set up.…”

Section: Nanotechnology and Nanosuspensionmentioning

confidence: 99%

“…It was found using a zetasizerano ZS (Malvern Instruments; Malvern; UK). 1,6 Drug content 100mg of cefixime was taken and dissolved completely on 100ml of 0.1N HCl in a volumetric flask. From above solution; 10ml was withdrawn and diluted to 100ml in a volumetric flask and then analysed in UV Spectrophotometer at a wavelength of 287nm.…”

Section: Zeta Potentialmentioning

confidence: 99%

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Mastiholimath¹,

Rajendra²,

Mannur³

et al. 2019

IJPER

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Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol and Millipore water was used as solvent and antisolvent respectively. The surfactants used for the preparation were PVP K30 and HPMC K100 which was found to be compatible in the formulation. Compatibility of the drug and drug with its excipients was found out by FTIR studies. Characterization of the optimized Cefixime Nanosuspension was carried out by particle size analysis, Differential Scanning Calorimetry, Zeta Potential, Drug content, in-vitro drug release studies, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy(TEM). The antimicrobial activity of cefixime nanosuspension was done by Disk diffusion method against E. coli performed in nutrient agar with different concentrations of the formulation. The Minimum Inhibitory Concentration (MIC) was determined by calculating Zone of inhibition. A method was developed forcefixime nanosuspension and validated by High Performance Thin Layer Chromatography (HPTLC). Results: The optimizedcefixime nanosuspension was validated for Identification, Linearity, Specificity, Precision and Recovery. The Recovery of cefixime nanosuspension was found to be 95.57%.

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“…Formation of nanoparticles could provide some benefits such as increased saturation solubility and drug dissolution rate, improved bioavailability and dose proportionality, and inter-subject variability in comparison with the coarse or micronized drug powder. 5…”

Section: Importance Of Antibiotics As Nanosuspensionmentioning

confidence: 99%

Antibiotics Nanosuspension: A Review

Mathew

Krishnakumar

Dineshkumar

et al. 2017

J. Drug Delivery Ther.

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Nanosuspensions are colloidal dispersions and biphasic system consisting of drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1μm in size. Many drugs including antibiotics are having poor solubility. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving bioavailability of such drugs with low solubility. This review describes the methods of pharmaceutical nanosuspension of antibiotic formulations and pharmaceutical applications in drug delivery.

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Optimization of Cefixime Nanosuspension to Improve Drug Dissolution

Cited by 8 publications

References 23 publications

Laponite‐Based Nanomaterials for Drug Delivery

Laponite‐Based Nanomaterials for Drug Delivery

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development

Antibiotics Nanosuspension: A Review

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