2018
DOI: 10.1208/s12249-018-1137-6
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Optimization of Ciprofloxacin Hydrochloride Spray-Dried Microparticles for Pulmonary Delivery Using Design of Experiments

Abstract: Ciprofloxacin is a broad-spectrum antibiotic for treatment of pulmonary diseases such as chronic obstructive pulmonary disease and cystic fibrosis. The purpose of this work was to rationally study the spray drying of ciprofloxacin in order to identify the formulation and operating conditions that lead to a product with aerodynamic properties appropriate for dry powder inhalation. A 2 fractional factorial design was applied to investigate the effect of selected variables (i.e., ciprofloxacin hydrochloride (CIP)… Show more

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Cited by 15 publications
(5 citation statements)
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“…Research efforts are focused on the development of novel formulations with advanced physical, biological, and/or chemical functional properties, as well as the advance in process understanding, modeling, scale-up, and control. Novel and specialized spray-dried (SD) products such as microparticles containing plasmid nanocomplex, microparticles of ciprofloxacin hydrochloride for pulmonary delivery, and hollow spherical aggregates of silica nanoparticles are a strong focus of research. These works and many others have also demonstrated the importance of understanding the impact that variations in the process conditions and input materials can have on the CQA of the products.…”
Section: Introductionmentioning
confidence: 99%
“…Research efforts are focused on the development of novel formulations with advanced physical, biological, and/or chemical functional properties, as well as the advance in process understanding, modeling, scale-up, and control. Novel and specialized spray-dried (SD) products such as microparticles containing plasmid nanocomplex, microparticles of ciprofloxacin hydrochloride for pulmonary delivery, and hollow spherical aggregates of silica nanoparticles are a strong focus of research. These works and many others have also demonstrated the importance of understanding the impact that variations in the process conditions and input materials can have on the CQA of the products.…”
Section: Introductionmentioning
confidence: 99%
“…Ung et al [ 22 ] explored insulin microspheres bypassing the extra-thoracic deposition and achieving maximum lung deposition. Razuc et al [ 23 ] successfully formulated ciprofloxacin microspheres using simple and green spray drying technology with high yield and excellent powder flow characteristics. In view of these findings, encapsulating dexamethasone in microspheres seems to be a potential approach for targeting it to lungs.…”
Section: Introductionmentioning
confidence: 99%
“…This approach bridges the research drive towards model-based methods for spray drying and the goals of QbD in the pharmaceutical industry. Previous research in these lines has focused on developing models for spray drying [1,[12][13][14][15][16] or on QbD for spray drying using the design of experiments and defining the design space based on statistical analysis of the experimental data [17][18][19][20]. In this work, the focus is put first on the evaluation of the methods to apply GSA to the spray drying process, followed by the critical analysis of the results to demonstrate its potential to exploit the knowledge of the system contained in the model.…”
Section: Introductionmentioning
confidence: 99%