Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design

Kumar, Abdhesh; Garg, Tarun; Sarma, G. S.; Rath, Goutam; Goyal, Amit K.

doi:10.1016/j.ejps.2015.01.012

Cited by 38 publications

(13 citation statements)

References 22 publications

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“…The configuration of xyloglucan gives the product a “mucin-like” molecular structure, thus conferring optimal mucoadhesive properties [ 46 ]. The good mucoadhesive properties of xyloglucan are attributed to the ramifications of xylose and galactoxylose, conferring a configuration similar to mucin [ 57 , 58 ]. The secondary hydroxyl groups present in xyloglucan are principally responsible for mucoadhesion and confer an anionic charge [ 42 ].…”

Section: General Properties Of Xyloglucan and Other Polymersmentioning

confidence: 99%

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

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Gómez‐Guillén

Montero

2018

IJMS

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Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic. Xyloglucan, a natural polysaccharide derived from tamarind seeds, possesses a “mucin-like” molecular structure that confers mucoadhesive properties, allowing xyloglucan formulations to act as a barrier capable of reducing bacterial adherence and invasion and to preserve tight junctions and paracellular flux, as observed in different in vitro and in vivo studies. In clinical trials, xyloglucan has been seen to reduce symptoms of gastroenteritis in adults and children, nasal disorders and dry eye syndrome. Similar mucosal protectors containing reticulated proteins have also been useful for the treatment of irritable bowel syndrome and urinary tract infections. The role of xyloglucan in other disorders with mucosal disruption, such as dermatological or other infectious diseases, deserves further research. In conclusion, xyloglucan, endowed with film-forming protective barrier properties, is a safe non-pharmacological alternative for the management of different diseases, such as gastrointestinal and nasal disorders.

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Section: General Properties Of Xyloglucan and Other Polymersmentioning

confidence: 99%

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Piqué

Gómez‐Guillén

Montero

2018

IJMS

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“…TG containing formulations showed anomalous drug release and were found to be safe for nasal administration. Pharmacokinetic study in rabbits showed improved nasal bioavailability of drug over oral route [143] . Recently, it has been proved that mucoadhesive microparticles (10µm) of TG can achieve selective deposition and retention of drug in the olfactory mucosa [144] .…”

Section: Nasal Drug Deliverymentioning

confidence: 98%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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“…Dendrimers generally have large interior void space which may be used to encapsulate or incorporate small drug molecules which help to reduce their toxicity and facilitate its controlled or targeted drug release (Thomas et al, 2008). Dendrimer solution has lower viscosity than the linear polymers (Kumar et al, 2015). The presence of many chain-ends or functional groups in dendrimers is responsible for high solubility, reactivity and miscibility (Sharma et al, 2015).…”

Section: Dendrimermentioning

confidence: 99%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

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Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design

Cited by 38 publications

References 22 publications

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

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