Optimization of complex for high-loss substance permittivity measurements

Krasov, P. S.; Arkhipova, Ekaterina A.; Fisun, A.I.

doi:10.1109/msmw.2010.5546088

Cited by 2 publications

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“…Previous results on CRC measurements of distilled water and ethanol solutions showed an improved sensitivity of the modified sensor [5,6]. As for now, it was interesting to evaluate the accuracy of permittivity values of biological samples.…”

Section: A) B ) C )mentioning

confidence: 93%

“…Figure 1. A picture (а) and the models of a sensor: reference structure (b) and modified by matching inserts (c); d 1 -d 5 are thickness of gaskets It has been revealed previously [5,6] that modification of the reference structure ( Fig.1b) by additional matching elements of different geometries and proportions lead to the change in measuring sensitivity of the CRC. Thus, application of asymmetrical wedge-insert increased in the measuring sensitivity twofold in magnitude and in 4 times in phase of the CRC compared to the reference structure.…”

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confidence: 99%

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Modified waveguide sensor for millimeter dielectric study of human erythrocytes in medical research

Arkhypova

Krasov

Fisun

2013

2013 International Kharkov Symposium on Physics and Engineering of Microwaves, Millimeter and Submillimeter Waves

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The effective evaluation of patients' health status in the rehabilitation process as well as the search for potential monitoring methods has always been of paramount importance to medicine. So the study of physicochemical characteristics of blood, in parallel with clinical analysis, allows obtaining more information about the state of health at the cellular level. In particular, change in the dielectric properties of erythrocytes in millimeter range indicates a change of their water content being an important criterion of physiological state [1,2]. To detect this dielectric behavior of cell water in blood the waveguide dielectrometry method based on complex reflection coefficient (CRC) measurements has been used. The outstanding features of this method are twofold: i) dielectrometer operates at a fixed frequency (39.5 GHz) that corresponds to γ-dispersion domain 1 and the size of the sensor enables to make measurements in the microsampling mode (5-6 μl); ii) as the measuring sensor is used waveguide cuvette modified by dielectric inserts. Measuring system based on reflectometer with a six-port measuring line was described in detail previously [3,4].The goal of current work is to demonstrate the improvement of the measuring sensitivity by the use of modified waveguide sensor as well as its potential for application in clinical research.Waveguide sensor is one of the most important elements of the complex. It is a short-circuited segment of rectangular waveguide with cross-section of 5.2x2.6 mm which holds up to 7-8 μl of sample (sample thickness is about 100 μm). Fig. 1 shows a picture of such sensor as well as its 3d-models (the upper wide and side walls of waveguide in model are not shown for clarity). Arrows indicate the direction of the incident (1) and reflected (2) electromagnetic waves. Figure 1. A picture (а) and the models of a sensor: reference structure (b) and modified by matching inserts (c); d 1 -d 5 are thickness of gaskets It has been revealed previously [5,6] that modification of the reference structure (Fig.1b) by additional matching elements of different geometries and proportions lead to the change in measuring sensitivity of the CRC. Thus, application of asymmetrical wedge-insert increased in the measuring sensitivity twofold in magnitude and in 4 times in phase of the CRC compared to the reference structure. Sensitivity shift or so-called "resolution enhancement" of this sensor is due to the changes in the waveguide-load matching. The result is great of interest to measure permittivity of low concentration solutions as well as biological samples that are characterized by small effect sizes. a) b ) c )Here we used sensor modified by the asymmetrical wedge-insert (Fig. 1c). As opposed to parallel-plate structure the calibration algorithm for the modified one has not been implemented that is required to find the values of sample permittivity. For a given sensor finding of permittivity has been solved for the first time and realized by solving the direct and inverse problems of electrodynamics us...

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Section: A) B ) C )mentioning

confidence: 93%

mentioning

confidence: 99%

Modified waveguide sensor for millimeter dielectric study of human erythrocytes in medical research

Arkhypova

Krasov

Fisun

2013

2013 International Kharkov Symposium on Physics and Engineering of Microwaves, Millimeter and Submillimeter Waves

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“…3 shows the models of used waveguide sensor. We have found previously that the modification of the reference cuvette (parallel-plate waveguide structure) by additional matching elements leads to the improved measuring performance [9,10]. In this case, we used the sensor modified by wedge-shaped dielectric insert (Fig.…”

Section: A Microwave Waveguide-based Dielectrometrymentioning

confidence: 99%

Microwave waveguide-based dielectrometry for the monitoring erythrocytes' beta-receptors activity

Arkhypova

Krasov

Fisun

et al. 2014

2014 44th European Microwave Conference

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In the present work we propose a new integrated approach to characterization of cellular reactivity using human erythrocytes in health and disease. We have applied two methods -microwave waveguide-based dielectrometry (39.5 GHz) and osmotic fragility technique based on photometry -to monitor receptor-specific response of blood cells caused by the beta-blocker exposure. Our results showed that dielectric response of erythrocytes depends on the physiological state of blood donors that is in good agreement with the degree of their beta-receptors activity (beta-ARM index). We found that druginduced changes in complex permittivity and the values of beta-ARM index are inversely related. The proposed approach is intended to supplement current cellular analysis used for healthcare, which will allow obtaining more information about health status of the patients at the cellular level.

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Optimization of complex for high-loss substance permittivity measurements

Cited by 2 publications

References 3 publications

Modified waveguide sensor for millimeter dielectric study of human erythrocytes in medical research

Modified waveguide sensor for millimeter dielectric study of human erythrocytes in medical research

Microwave waveguide-based dielectrometry for the monitoring erythrocytes' beta-receptors activity

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