Optimization of Copaiba oil-based nanoemulsions obtained by different preparation methods

Dias, Daiane; Colombo, Mariana; Kelmann, Regina Gendzelevski; Kaiser, Samuel; Lucca, Letícia Grolli; Teixeira, Hélder Ferreira; Limberger, Renata Pereira; Veiga, Valdir Florêncio da; Koester, Letícia Scherer

doi:10.1016/j.indcrop.2014.05.007

Cited by 68 publications

(42 citation statements)

References 36 publications

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“…Dias et al. demonstrated that the microcapsule suspension could be preserved for 90 days at 4 °C, but the caryophyllene had a certain volatilization at 25 °C (Dias et al., ). However, Flores et al.…”

Section: Resultsmentioning

confidence: 99%

Controlled Release Mechanism and Antibacterial Effect of Layer‐By‐Layer Self‐Assembly Thyme Oil Microcapsule

Zhang

et al. 2019

Journal of Food Science

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Thyme essential oil‐loaded microcapsules (TMS) were fabricated using natural polysaccharide chitosan (CS) and sodium alginate (SA) as the shell material via the method of layer‐by‐layer (LBL) assembly. The accumulated release rates of thyme oil and microcapsules at 4 °C were 42.50% and 10.16%, respectively. After heating at 100 °C for 5 hr, the release rate of the 0, 2, 4, 6 layers assembled microcapsules were 100%, 48.84%, 28.38%, 19.3%, severally. Microcapsules also had good pH sensitivity in the range of 4 to 10. Antimicrobial function studies showed that the microcapsules are more effective than thyme oil for three tested microorganisms. When the temperature rose from 37 °C to 121 °C, the antibacterial zone of thyme oil gradually decreased from 18.5 ± 0.6 mm to 12.3 ± 0.6 mm, although inhibition rate of microcapsules increased from 87.97% to 99.75%. The antibacterial effect of thyme oil declined with the increase of pH, in terms of microcapsules, the efficiency was better under acidic or alkaline conditions. The thyme oil microcapsules can suppress the growth of Staphylococcus aureus in milk and prolong its shelf life. It was determined that this microcapsule could be a potential alternative as a natural antimicrobial agent in food and pharmaceutical industries. Practical Application This work provided release performance and mechanism of layer‐by‐layer (LBL) thyme oil microcapsule under different conditions, and further studies showed its antibacterial ability to explore how herb essential oils can be potentially applied in food packaging and antibacterial areas.

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Section: Resultsmentioning

confidence: 99%

Controlled Release Mechanism and Antibacterial Effect of Layer‐By‐Layer Self‐Assembly Thyme Oil Microcapsule

Zhang

et al. 2019

Journal of Food Science

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“…All of them presented high negative zeta potential values. Adsorption of hydroxyl groups and/or conjugated bases of secondary metabolites, which naturally occur on some natural oils, at the surface of micelles has been associated to this phenomenon [35]. Thus, dissociation of some substances from sucupira oleoresin, such as fatty acids and others (e.g.…”

Section: Resultsmentioning

confidence: 99%

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

et al. 2017

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BackgroundPreparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis. Thus, we aimed to investigate influence of different pairs of surfactants in nanoemulsion formation and investigate if a sucupira oleoresin-based nanoemulsion has promising larvicidal activity against this C. quinquefasciatus. We also evaluated morphological alteration, possible mechanism of insecticidal action and ecotoxicity of the nanoemulsion against a non-target organism.ResultsAmong the different pairs of surfactants that were tested, nanoemulsions obtained with polysorbate 80/sorbitan monooleate and polysorbate 80/sorbitan trioleate presented smallest mean droplet size just afterwards preparation, respectively 151.0 ± 2.252 and 160.7 ± 1.493 nm. They presented high negative zeta potential values, low polydispersity index (<0.300) and did not present great alteration in mean droplet size and polydispersity index after 1 day of preparation. Overall, nanoemulsion prepared with polysorbate 80/sorbitan monooleate was considered more stable and was chosen for biological assays. It presented low LC50 value against larvae (34.75; 7.31–51.86 mg/L) after 48 h of treatment and some morphological alteration was observed. The nanoemulsion did not inhibit acetylcholinesterase of C. quinquefasciatus larvae. It was not toxic to green algae Chlorella vulgaris at low concentration (25 mg/L).ConclusionsOur results suggest that optimal nanoemulsions may be prepared with different surfactants using a low cost and low energy simple method. Moreover, this prototype proved to be effective against C. quinquefasciatus, being considered an ecofriendly novel nanoproduct that can be useful in integrated control programs of vector control.

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“…Dias et al (2012Dias et al ( , 2014 compared high pressure homogenization and spontaneous emulsification in order to prepare cobaiba oil nanoemulsion. Copaiba oil (Copaifera multijuga) is an oleoresin that can be directed collect from the tree trunk.…”

Section: Essential Oilsmentioning

confidence: 99%

On the use of nanotechnology-based strategies for association of complex matrices from plant extracts

Zorzi

Carvalho

Poser

et al. 2015

Revista Brasileira de Farmacognosia

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Please cite this article in press as: Zorzi, G., et al. On the use of nanotechnology-based strategies for association of complexes matrices from plant extracts. Revista Brasileira de Farmacognosia (2015), http://dx.BJP 159 1-11 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c tDepending on the method of extraction, plant extracts can contain an enormous variety of active molecules, such as phenolic compounds, essential oils, alkaloids, among others. In many cases, from a pharmacological point of view, it is interesting to work with crude extract or fractions instead of a single isolated compound. This could be due to multi-targeting effect of the extract, lack of knowledge of the active compounds, synergistic effect of the extract compounds, among others. In any case, in order to achieve a final product some issues must be overcome, including poor stability, solvent toxicity, and low solubility of the bioactive compound. Recently many nanotechnology-based strategies have been proposed as an alternative to solve these problems, especially liposomes, nanoemulsions and nanoparticles. In this sense, the present work aims to review the main nanotechnological approaches used for association of different plant extracts and the main achievements form using these technologies.

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Optimization of Copaiba oil-based nanoemulsions obtained by different preparation methods

Cited by 68 publications

References 36 publications

Controlled Release Mechanism and Antibacterial Effect of Layer‐By‐Layer Self‐Assembly Thyme Oil Microcapsule

Controlled Release Mechanism and Antibacterial Effect of Layer‐By‐Layer Self‐Assembly Thyme Oil Microcapsule

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

On the use of nanotechnology-based strategies for association of complex matrices from plant extracts

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