Optimization of Cordyceps sinensis fermentation Marsdenia tenacissima process and the differences of metabolites before and after fermentation

Wang, Siqi; Lu, Lin; Song, Tianyuan; Xu, Xinxin; Yu, Jie; Liu, Tongxiang

doi:10.1016/j.heliyon.2022.e12586

“…It has been reported that water extract of Cordyceps could reduce oxidative stress (Chu et al 2011;Bai et al 2018), and Paecilomyces tenuipes extract could also alleviate oxidative stress and have antioxidant effects (Li et al 2019). Products using a two-way liquid fermentation process are either directly applied to fungal powder extracts, while others extract active ingredients such as polysaccharides before being used in medicine (Wang et al 2022). Therefore,…”

Section: Evaluation Of Antioxidant Activitymentioning

confidence: 99%

“…Although the mixed fermentation of fungi and TCM has become a hot topic (Wang et al 2022;Wang et al 2023;He et al 2024), and a large number of studies have reported that Cordyceps polysaccharides and polyphenols have strong antioxidant activity, but few reports have reported the effect of Cordyceps nucleotides on antioxidant activities (Van et al 2022;Jiang et al 2023;Tang et al 2022). However, it has not been reported that increasing the nucleotide content of C. tenuipes by mixing fermentation with TCM and optimizing the fermentation process can improve antioxidant activity and AD.…”

Section: Introductionmentioning

confidence: 99%

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects

Li,

Zhu,

Li

et al. 2024

Arch Microbiol

0

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Nucleotides are important components and the main indicators for judging Cordyceps quality. To increase the nucleoside content of Cordyceps tenuipes for enhancing the efficacy activity. In this paper, the mixed fermentation process of Schisandra chinensis and C. tenuipes was systematically studied, and it was proposed that the fermentation products aqueous extract (S-ZAE) had antioxidant activity and anti-AChE ability. Herein, the results of a single factor showed that S. chinensis, yeast extract, inoculum amount, and pH had significant effects on nucleotide synthesis, and these four factors were used as the factor of response surface optimization. The results of response surface optimization were 3% glucose, 0.25% KH2PO4, 2.1% yeast extract, and S. chinensis 0.49% (m/v), the optimal fermentation conditions were 25℃, inoculum 5.8% (v/v), pH 3.8, 6 d. The yield of total nucleotides in the scale-up culture was 0.64 ± 0.027 mg/mL, which was 10.67 times that before optimization, and S-ZAE has good antioxidant and anti-AChE activities. This fermentation method has the advantage of industrialization, and its fermentation products have the potential to become good functional foods or natural therapeutic agents.

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“…Although the mixed fermentation of fungi and TCM has become a hot topic (Wang et al 2022;Wang et al 2023;He et al 2024), and a large number of studies have reported that Cordyceps polysaccharides and polyphenols have strong antioxidant activity, but few reports have reported the effect of Cordyceps nucleotides on antioxidant activities (Van et al 2022;Jiang et al 2023;Tang et al 2022). However, it has not been reported that increasing the nucleotide content of C. tenuipes by mixing fermentation with TCM and optimizing the fermentation process can improve antioxidant activity and AD.…”

Section: Introductionmentioning

confidence: 99%

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects

Li,

Zhu,

Li

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Nucleotides are important components and the main indicators for judging Cordyceps quality. To increase the nucleoside content of Cordyceps tenuipes for enhancing the efficacy activity. In this paper, the mixed fermentation process of Schisandra chinensis and C. tenuipes was systematically studied, and it was proposed that the fermentation products aqueous extract (S-ZAE) had antioxidant activity and anti-AChE ability. Herein, the results of a single factor showed that S. chinensis, yeast extract, inoculum amount, and pH had significant effects on nucleotide synthesis, and these four factors were used as the factor of response surface optimization. The results of response surface optimization were 3% glucose, 0.25% KH2PO4, 2.1% yeast extract, and S. chinensis 0.49% (m/v), the optimal fermentation conditions were 25℃, inoculum 5.8% (v/v), pH 3.8, 6 d. The yield of total nucleotides in the scale-up culture was 0.64 ± 0.027 mg/mL, which was 10.67 times that before optimization, and S-ZAE has good antioxidant and anti-AChE activities. This fermentation method has the advantage of industrialization, and its fermentation products have the potential to become good functional foods or natural therapeutic agents.

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Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective

Zhang,

Yan

et al. 2024

Trends in Food Science & Technology

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Optimization of Cordyceps sinensis fermentation Marsdenia tenacissima process and the differences of metabolites before and after fermentation

Cited by 4 publications

References 53 publications

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects

Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective

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