Optimization of culture medium and scale-up production of astaxanthin using corn steep liquor as substrate by response surface methodology

Diversity, astaxanthin production, and genomic analysis of Rhodotorula paludigena SP9-15

“…Hence, based on the results obtained, an initial pH of 7.5 was determined to be the optimal pH for the production medium to achieve maximum astaxanthin production by R. paludigena SP9-15 in the optimized medium supplemented with 40 g/L glucose. Like Guan et al [ 56 ], optimal medium conditions for culturing P. rhodozyma D3 were 32 g/L glucose, 12 g/L corn steep liquor as the nitrogen source, and an initial pH of 6.7. Under these conditions, P. rhodozyma D3 achieved a biomass of 6.47 g/L and an astaxanthin content of 1.41 mg/g.…”

Transcriptomics analysis and fed-batch regulation of high astaxanthin-producing Phaffia rhodozyma/Xanthophyllomyces dendrorhous obtained through adaptive laboratory evolution

“…Guan et al. ( 2022 ) added 500 mg/L of TiO 2 to the culture medium, thereby making the astaxanthin content of P. rhodozyma reach 4.7 mg/g, which is significantly higher than that of the original strain. However, the direct addition of TiO 2 during fermentation has significant limitations, facing problems such as TiO 2 separation and unstable yields, while the yield of P. rhodozyma astaxanthin is low when no TiO 2 is added.…”