For the hypoid gear pair of the heavy-duty vehicle drive axle machined by the duplex helical method, in order to avoid edge contact and stress concentration on the tooth surface, a four-segment tool profile is designed to modify the concave and convex surfaces simultaneously. First, the geometric model of the four-segment tool profile is established. Second, the mathematical model of the duplex helical method based on the four-segment tool profile is established, and the method of solving the tooth surface generated by the connecting points of the four-segment tool profile is given. Finally, the finite element method of loaded tooth contact analysis is used to analyze the meshing performance of the gear pair obtained by the four-segment tool profile modification, and the results are compared with the original gear pair. The results show that after the tooth surfaces are modified, the edge contact of the tooth surfaces are avoided, the stress distribution of the tooth surfaces are improved, the maximum contact stress of the tooth surfaces are reduced, and the fatigue and wear life of the tooth surface are improved.