Optimization of dialysate flow and mass transfer during automated peritoneal dialysis

Measurement of hydrostatic intraperitoneal pressure: a useful tool for the improvement of dialysis dose prescription

“…But fill volume increase, i.e. individually optimized, will allow the recruitment of peritoneal membrane contact area and could increase dialysis effectiveness [18,19,20,21,22] (Table 3). On the contrary, too small a fill volume is associated with peritoneal membrane hyperpermeability with potential risks of morbidity or even mortality in adults [1,2,3].…”

Intraperitoneal distribution imaging in ovarian cancer patients

“…In addition, no studies comparing different techniques of administration of chemotherapy in this patient population have been performed. Previous studies of peritoneal dialysis techniques have concluded that dialysate volumes and patient position both impact on the effectiveness of peritoneal exchange 22,23 . During IP drug administration, it therefore appears important to optimize the volume in which the drug is delivered and to consider patient position as an important determinant of drug distribution.…”

Peritoneal Dialysis in Children

“…In fact, peritoneal catheter drainage profile is not linear, since a high flow rate is maintained until a critical intraperitoneal volume is reached. After this point, also called breakpoint, the flow rate drops and during the final, slow-flow period of the drainage phase, the peritoneal cavity is almost empty and solute clearance greatly reduced [33]. Since the critical intraperitoneal volume is an individual characteristic, tailoring tidal volume to the drainage profile of each patient reduces idle time and improves the overall efficiency of the system.…”