Optimization of Different Key Culture Conditions for Enhanced Biodegradation of a Refractory Emerging Pollutant by a Bacterial Isolate Through a Statistical Approach

Ungureanu, Claudia Popa; Favier, Lidia; Bahrim, Gabriela

doi:10.1007/978-3-319-70548-4_82

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“…These compounds are considered as emergent environmental contaminants and exhibit moderate to high persistence to environmental degradation in correlation with their chemical structure and toxicity. It is important to notice the important environmental impact of the continuous release of pharmaceuticals into the aquatic system posing a serious ecotoxicological risk for the aquatic wildlife (Popa Ungureanu et al, 2018Harja et al, 2020). To date, the wastewater treatment plants (WWTPs) are considered as one of the major sources of contamination of natural water bodies (Yehya et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the biodegradation efficiency of a emergent refractory water pollutant by a bacterial isolate through a statistical process optimization approach

Favier

Ungureanu

Simion

et al. 2021

Process Safety and Environmental Protection

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Clofibric acid, the main pharmacologically-active metabolite of pharmaceutical products used as antilipaemic agent has received, in last years, an increased interest because of its wellknown recalcitrance to biodegradation and its high persistence in the aquatic environment. This molecule passes unchanged or poorly transformed in wastewater treatment plants. An indigenous strain of Streptomyces, named MIUG 4.89 was previously selected, exhibited the ability to favor clofibric acid biodegradation within submerged cultivation in controlled biotechnological conditions. Thus, in order to enhance the biodegradation of this refractory molecule, mathematical modeling and statistical optimization designs associated to Plackett-Burman Design and Response Surface Methodology were used to evaluate and optimize the effects of different major culture conditions of this bacterial isolate. According to the results, under optimized culture conditions (5 g L -1 glucose, inoculation level 4.7%, 27.5°C and 20 days of incubation) the strain Streptomyces MIUG 4.89 exhibited a successful removal of clofibric acid with a biodegradation yield of 54%, which is in agreement with model J o u r n a l P r e -p r o o f 3 prediction. Thus, under optimized conditions, the removal yield was enhanced, which is very promising accounting for the refractory character of this water pollutant.

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Section: Introductionmentioning

confidence: 99%