The unbalance vibration characteristics of dual-rotor system were fully analyzed based on design of experiment in this paper. Firstly, a simplified dual-rotor system was presented with the consideration of radial stiffness and damping of bearing supports and modelled in ADAMS so that multi-body dynamic simulations could be carried out. Subsequently, the unbalance parameters of a single unbalanced disk were sampled by experimental design method, and then vibration responses in multiple unbalance conditions were obtained via the simulations in ADAMS which results showed the response ranges at measuring points, vibration transmission routes and the definite proportional relations of vibration responses among different speeds, as well as, there was the correlation between the unbalance parameters and the response amplitude. Finally, studies about the double unbalanced discs severally in low-and high-pressure rotors were conducted, and the similar laws were summed up; more importantly, there were consistencies with the case of the single unbalanced disk in terms of the vibration amplitude ranges and the constant proportionality relationship of amplitudes among different rotating speeds, as well as the correlation between unbalance parameters and response amplitude. The presented results offer significant and incisive understanding for the dynamic performances of an unbalanced dual-rotor system.