This work focuses in the use of Fenton reagent and UV-irradiation, in a lab-scale experiment, for the treatment of real dye wastewater coming from a Spanish textile manufacturer.Response surface methodology (RSM) and a 2 3 factorial design were used to evaluate the effects of the three independent variables considered for the optimization of the oxidative process: temperature, Fe (II) and H 2 O 2 concentrations, for a textile wastewater generated during a dyeing process with chemical oxygen demand (COD) of 1705 mg·L -1 O 2 at pH = 3. Wastewater degradation was followed in terms of COD decrease.In the optimization, the correlation coefficients for the model (R The combination of Fenton, Fenton-like and photon-Fenton reactions has been proved to be highly effective for the treatment of such a type of wastewaters, and several advantages for the technique application arise from the study. Under these conditions, 120 min of treatment resulted in a 62.9 % and 76.3 % decrease in COD after Fenton and photo-Fenton treatments respectively.