2015
DOI: 10.1155/2015/819067
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Optimization of Gentisides Extraction fromGentiana rigescensFranch. ex Hemsl. by Response Surface Methodology

Abstract: Gentisides are a class of chemical compounds which is considered as potential therapeutic substance for treatment of neurodegenerative disorders. The heat reflux extraction conditions were optimized for seven kinds of gentisides from the root and rhizome of Gentiana rigescens Franch. ex Hemsl. by employing response surface method. Based on univariate test, a Box-Behnken design (BBD) was applied to the survey of relationships between response value (gentisides yield) and independent variables which were chosen … Show more

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Cited by 6 publications
(3 citation statements)
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“…Particularly, peaks at 1666, 1608, 1276, 933, and 844 cm −1 make the most contributions to the prediction. The peak at 1666 cm −1 may be due to carbonyl group [ 17 ]. The peaks at 1610 and 1276 cm −1 may be results of terpene compounds, while the bands located at 933 and 844 cm −1 may be caused by vibrations of sugar moieties related to glycoside [ 42 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Particularly, peaks at 1666, 1608, 1276, 933, and 844 cm −1 make the most contributions to the prediction. The peak at 1666 cm −1 may be due to carbonyl group [ 17 ]. The peaks at 1610 and 1276 cm −1 may be results of terpene compounds, while the bands located at 933 and 844 cm −1 may be caused by vibrations of sugar moieties related to glycoside [ 42 ].…”
Section: Resultsmentioning
confidence: 99%
“…This plant has been recorded in Chinese Pharmacopoeia (2015 version) for treatments of rheumatism, convulsion, and jaundice [ 13 ]. Up to now, many reports have demonstrated that its health benefits are mainly related to iridoid glycosides, including gentiopicroside, swertiamarin, sweroside, and loganic acid ( Figure 1 ) [ 14 17 ]. Especially, gentiopicroside has been regarded as the marker component of G. rigescens to evaluate its quality in Chinese Pharmacopoeia [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…To determine optimal conditions acid concentration, solid/liquid ratio, and temperature in order to define the optimal parameters allowing the maximum dissolution of the rare earths, the responses are optimized simultaneously using the desirability function included in the Nemrod software. The desirability function varies in the interval [0, 1]; the value 1 corresponds to the maximum satisfaction (desired value) and 0 corresponds to an unacceptable response (Hammas-Nasri, Horchani-Naifer, Férid, & Barca, 2016 ;Maguana et al, 2018 ;Zhang, Gu, Ahmad, & Huang, 2017 ;Chu et al, 2015). The maximum of the function D gives the best global compromise for all the responses in the studied domains and corresponds to optimal experimental conditions.…”
Section: Optimizationmentioning
confidence: 99%