1997
DOI: 10.2337/diab.46.7.1207
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Optimization of Glycemic Control by Insulin Therapy Decreases the Proportion of Small Dense LDL Particles in Diabetic Patients

Abstract: Small dense LDL particles (B phenotype) are considered to be more atherogenic than large buoyant LDL particles. The influence of glycemic control on LDL particle size and density is still under debate. The aim of this study was to determine LDL subfraction phenotype in both IDDM and NIDDM patients in poor glycemic control compared with that of respective matched control groups. In addition, we evaluated the effect of a 3-month period of optimized glycemic control on this parameter. Thirty-seven IDDM patients a… Show more

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Cited by 59 publications
(47 citation statements)
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“…Recent data suggest that about 40 to 50% of Type 2 diabetic patients have a preponderance of small dense LDL particles [109,110,111]. There is a stepwise decrease of LDL size when subjects with normal glucose tolerance are compared to those with impaired glucose tolerance and clinical diabetes [108].…”
Section: Is Postprandial Lipidemia a Hazard?mentioning
confidence: 99%
“…Recent data suggest that about 40 to 50% of Type 2 diabetic patients have a preponderance of small dense LDL particles [109,110,111]. There is a stepwise decrease of LDL size when subjects with normal glucose tolerance are compared to those with impaired glucose tolerance and clinical diabetes [108].…”
Section: Is Postprandial Lipidemia a Hazard?mentioning
confidence: 99%
“…Currently, evidence is accumulating that insulin therapy in diabetic patients has rather beneficial effects on the cardiovascular system. It has been shown to normalise lipid abnormalities by reducing total plasma triglycerides and increasing plasma HDL-cholesterol, and also to improve endothelial function, determined by measuring forearm blood flow responses to endothelium-dependent vasodilators [5,6,9,10]. Furthermore, insulin exerts anti-inflammatory effects, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…Such changes include decreases in serum triglyceride, 18,35,36 FFA, 17,18,21 and glucose 37 concentrations, and all these parameters have been associated with endothelial function. 21,35 Acute increases in insulin concentrations also enhance ACh-induced vasodilatation.…”
Section: Vehkavaara Et Al Insulin Therapy and Endothelial Functionmentioning
confidence: 99%
“…17,[41][42][43] If this would also happen in vascular smooth muscle, it might provide one mechanism to explain enhanced vascular smooth muscle cell-dependent vasodilatation after insulin therapy. Other possible mechanisms include increased bioavailability of exogenous (and endogenous) nitrates due to decreases in oxidative stress, 44,45 advanced glycosylation end products, 46 small dense LDL particles, 22,36 and the susceptibility of circulating LDL to oxidation. 47 Serum FFAs have also been suggested to enhance endothelium-dependent, 21 and possibly endothelium-independent, 35 vasodilatation.…”
Section: Vehkavaara Et Al Insulin Therapy and Endothelial Functionmentioning
confidence: 99%