Optimization of Graft Polymerization and Performance of Carboxymethyl Chitosan / Polyacrylamide Flocculants

Mohamed, E. H.; Mansour, E. M. E.; Hassan, Hammed Ahmed Mohamed; Amaly, Noha; Hassan, Mohammed; Soliman, Emad A.

doi:10.5171/2014.351498

Cited by 11 publications

(4 citation statements)

References 29 publications

(17 reference statements)

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“…CM-Ch was extracted from Sarcophaga and Chrysomya larvae and commercial chitosan (Sigma-Aldrich) as previously described [ 22 ]. In brief, 10 g of chitosan from Sarcophaga , Chrysomya , and commercial chitosan were dispersed in 50 mL distilled water for 30 min, then 50 mL of isopropyl alcohol was added, and the samples spun at 300 rpm at room temperature for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Dipteran Carboxymethyl Chitosan as an Inexhaustible Derivative with a Potential Antiproliferative Activity in Hepatocellular Carcinoma Cells

Rahman

Ghaffar

Alkhuriji

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Traditional folk therapies indicate that insects have diverse medicinal potentials. However, the therapeutic application of insect chitosan and its derivatives has not been explored. To investigate the application of chitosan and its derivatives, the carboxymethyl derivative of chitosan (CM-Ch) was extracted from two dipteran larvae species, Chrysomya albiceps and Sarcophaga aegyptiaca. The degree of deacetylation (DD) and CM-Ch functional groups were validated using Fourier-transform infrared (FTIR) spectroscopy analysis and proton nuclear magnetic resonance spectroscopy (1H NMR), respectively. The molecular weight was estimated using MALDI-TOF MS analysis. The effect of CM-Ch on the morphology and proliferation of human liver HepG2 cancer cells was assessed. IC50 of CM-Ch induced significant growth-inhibitory effects in HepG2 cells. CM-Ch treatment altered the morphology of HepG2 in a dose-dependent manner and induced apoptosis in a caspase-dependent manner. CM-Ch treatment showed no signs of toxicity, and no alterations in liver and kidney biochemical markers were observed in albino rats. A CM-Ch derivative from commercial crustacean chitosan was used to assess the efficacy of the insect-derived CM-Ch. The data presented here introduce insect CM-Ch as a promising, inexhaustible, safe derivative of chitosan with antitumor potential in liver cancer. This is the first report highlighting the anticancer activity of insect CM-Ch in hepatocellular carcinoma cells.

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Section: Methodsmentioning

confidence: 99%

Dipteran Carboxymethyl Chitosan as an Inexhaustible Derivative with a Potential Antiproliferative Activity in Hepatocellular Carcinoma Cells

Rahman

Ghaffar

Alkhuriji

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…These modified polymers are also biodegradable and added positivity to be used as biomaterials [56]. Graft co-polymers of (kappa-carrageenan) with N,N-dimethylacrylamide and N-venyl formamide can be used for the treatment of coal mine waste water [137,138]. Corboxymethylation of gum and mucilages shows greater solubility, hydrophilicity and makes solution more clear.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents)

Malviya

Sharma

Dubey³

2016

Materials Science and Engineering: C

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“…Soliman et al produced amphoteric CM-CH-g-pAA (carboxymethyl chitosan-graft-polyacrylamide) copolymer using the peroxy graft copolymerization of acrylamide (AA) onto carboxymethyl chitosan (CM-CH) using potassium persulfate as initiator [ 56 ]. By employing potassium persulfate as an initiator, poly( N -vinyl imidazole) (pN-VI) grafting was carried out onto CM-CH in an aqueous solution [ 47 ].…”

Section: Derivatives Of Carboxymethylated Gums (Cmgs)mentioning

confidence: 99%

“…Epichlorohydrin opens the epoxy ring, forming a new epoxy macromolecular. Cross-linking forms a three-dimensional network and reduces polymer segment mobility [ 56 ]. Carboxymethylation and cross-linking improved swelling by 23%.…”

Section: Derivatives Of Carboxymethylated Gums (Cmgs)mentioning

confidence: 99%

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Baghel¹,

Sakure²,

Giri

et al. 2023

Pharmaceuticals

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Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.

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Optimization of Graft Polymerization and Performance of Carboxymethyl Chitosan / Polyacrylamide Flocculants

Cited by 11 publications

References 29 publications

Dipteran Carboxymethyl Chitosan as an Inexhaustible Derivative with a Potential Antiproliferative Activity in Hepatocellular Carcinoma Cells

Dipteran Carboxymethyl Chitosan as an Inexhaustible Derivative with a Potential Antiproliferative Activity in Hepatocellular Carcinoma Cells

Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents)

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

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