Cornelian cherry, a perennial plant belongs to Cornaceae family (Cornus mas), grows at high grounds in the form of small-bush trees.Cornelian cherry is cultivated in Europe, especially in the Czech Republic, Poland, and Slovakia (Rop et al., 2010). In recent years, production of cornelian cherry is also developed in Turkey. According to data of Turkish Statistical Institute, the production is approximately 11 tons/year in Turkey (Anonymus, 2017). Fruits of cornelian cherry are usually dark red, but are also available in pink or yellow. The average weight of the fruit is in the range of 5 to 8 g. Seed of the fruit constitutes approximately 7.5%-11% of the total fruit weight (Klimenko, 2004). Chemical analyses of cornelian cherry have shown that it has significant number of phenolic compounds (anthocyanins, flavonoids, flavanols, and phenolic acids; Dinda et al., 2016).Ultrasound is becoming more popular for the extraction of valuable compounds from food materials. Its principle is based on heat and mass transfer by providing cell wall destruction with cavitation effect. Ultrasound extraction has many advantages such as high penetration depth, high product efficiency, low solvent consumption, and preservation of heat sensitive products. Moreover, it can be easily integrated with other devices (Barba et al., 2016).In literature, ultrasound extraction has been widely used to extract valuable products (