The study of an in-line NIR multichannel spectrophotometer system is performed in terms of energy efficiency and uniformity of dynamic range in the fiber-optic bundle. Recommendations for choosing an optical design between the afocal and focal probing systems are formulated based on comparison of reflection and transmission operation principles as well as determination of working wavelength ranges and analysis of spectral characteristics of the entire system, from source to receiver. In result, for the afocal system, uniformity of 0.09 was achieved with an energy efficiency of 30.4 percent. A spectrophotometer with a combination of the focal forming system and sapphire windows in a flow cell can achieve a power variation coefficient of 0.165 with a power efficiency of 15.3%.