Liquid swine (Sus scrofa) manure (LSM) is a substantial crop nutrient resource in Iowa. An on-farm study was conducted in 2000-2003 at 16 sites to evaluate corn (Zea mays L.) response to LSM N. Replicated fi eld-length strips were a control and two LSM rates, fall or spring applied, and four fertilizer N (FN) rates applied aft er planting in subplots. Average corn grain yield (GY) in the strips was 7.8, 9.6, and 10.4 Mg ha -1 for the control, low, and high LSM rates, respectively. Plant and soil tests also increased with LSM application, indicating corn response. With the low LSM rate, GY increased with FN at many sites, but less frequent and smaller increase with the high LSM rate. Despite the average 82% fraction of LSM total-N as NH 4 -N, FN equivalence based on GY was only 61 to 64%. Th is indicates potential N losses, not unexpected due to application time and large springtime precipitation at some sites. Critical values for the late spring soil NO 3 -N (LSNT) and lower corn stalk NO 3 -N (CSNT) were 27 and 1820 mg NO 3 -N kg -1 , respectively; and the tests consistently indicated excess N but had poor relationship to N response at low values. Relative chlorophyll meter (RCM) values did not diff erentiate excess to slight N defi ciency. Th e LSM was able to supply N for corn production, but like fertilizer, must be managed carefully. If additional N may be needed to achieve optimal yield, application must be based on well-calibrated soil or plant tests.