Optimization of media components and fermentation conditions for citric acid production from sweet potato peel starch hydrolysate by Aspergillus niger

Aboyeji, O.O.; Oloke, Julius Kola; Arinkoola, A. O.; Oke, Mushaffa A.; Ishola, Mofoluwake M.

doi:10.1016/j.sciaf.2020.e00554

Cited by 21 publications

(19 citation statements)

References 17 publications

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“…A similar result was obtained by [35], in which the C/N ratio presented a statistically significant effect in the optimization of a medium for the production of organic acids in submerged fermentation of A. niger. Figure 7 shows, in detail, the contour lines of the response surface in a two-dimensional plane, with lines of constant absorbance in the form of envelopes that validate the results of the dimensional analysis and the bivariate Pearson correlations, where the C/N and C/K ratios, as dimensionless parameters, have a significant effect on the bioleaching of gold using fermented broths.…”

Section: Results Of the Mathematical Modelsupporting

confidence: 83%

“…The highest absorbance of the evaluated region was 0.096, which is achieved by producing a fermented broth with a C/N ratio close to 50 and in the vicinity of a C/K ratio close to 800. A similar result was obtained by [35], in which the C/N ratio presented a statistically significant effect in the optimization of a medium for the production of organic acids in submerged fermentation of A. niger.…”

Section: Results Of the Mathematical Modelsupporting

confidence: 83%

“…In many biotechnological processes, the relationship between the amount of carbon and other nutrients such as nitrogen has been reported as a relevant variable to characterize the nutritional balance for microorganisms, especially in fermentation processes; previous studies show how the C/N ratio must be close to 42 to optimize the production of organic acids or for bioremediation processes [34,35]. With the results obtained from the dimensional analysis, the functional relationship [36] is presented in the form of Equation ( 14).…”

Section: Experiments Numbermentioning

confidence: 99%

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Mathematical Model for Scaling up Bioprocesses Using Experiment Design Combined with Buckingham Pi Theorem

et al. 2021

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Scaling up bioprocesses from the experimental to the pilot or industrial scale involves heuristics and scale relationships that are far from the specific phenomena and are usually not connected to the experimental data. In complex systems, the scaling-up methodology must connect the experimental data with the tools of engineering design. In this work, a two-stage gold bioleaching process was used as a case study to develop a mathematical model of bioprocess scaling that combines the design of experiments with dimensional analysis using the Buckingham Pi theorem to formulate a predictive model that allows scaling up bioprocesses. It was found that the C/N, C/K, and T/C ratios are dimensionless factors that can explain the behavior of a system. Using the Pearson Product–Moment bivariate analysis, it was found that the dimensionless factors C/N and C/K were correlated with the leaching potential of the fermented broth at 1060 cm−1. With these results, a non-linear logarithmic model based on dimensionless parameters was proposed to explain the behavior of the system with a correlation coefficient of R2 = 0.9889, showing that the optimal conditions to produce fermented broth comprised a C/N ratio close to 50 and a C/K ratio close to 800, which allows predicting the scaling of the bioprocess.

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Section: Results Of the Mathematical Modelsupporting

confidence: 83%

Section: Results Of the Mathematical Modelsupporting

confidence: 83%

Section: Experiments Numbermentioning

confidence: 99%

See 1 more Smart Citation

Mathematical Model for Scaling up Bioprocesses Using Experiment Design Combined with Buckingham Pi Theorem

et al. 2021

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“…Based on equation 2 and the response surface, the maximum biomass production point of reaction was 5 days and 12 hours, inoculum 3.38 mm and 54.31 μL of benzonitrile with theoretical production of 1.82 g of wet biomass. The reaction time obtained (5 days and 12 hours) is within the average time interval for several species of A. niger, which is between 5 (Sattar, et al, 2019;Papadaki, et al, 2020;Putri, et al, 2020) and 7 days (Khan, et al, 2019;Aboyeji, et al, 2020). The volume of nitrile obtained from the statistical design used (CCD) revealed that the microorganism studied has resistance to nitrile since microorganisms generally have limited tolerance to high concentrations of nitriles due to their toxicity (Sattar, et al, 2019).…”

Section: Optimization Of Bioremediationmentioning

confidence: 67%

Potential of Aspergillus niger Tiegh 8285 in the bioremediation of water contaminated with benzonitrile

Mituishi

Menezes

Tavares

et al. 2022

RSD

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Benzonitrile is a compound found in pesticides. The use of these pesticides can cause environmental contamination, and the search for non-aggressive methods to eliminate these residues is necessary. In this study, fungi Aspergillus isolated from cocoa were investigated for their benzonitrile bioremediation potential. The fungi were cultured in a solid medium supplemented with nitrile and glucose (a), nitrile (b), and glucose (c). Independent variables: time, inoculum, and nitrile were optimized using a central composite design to determine the best microbial growth and wet biomass (dependent variable) as a response in the bioremediation process. A. niger Tiegh 8285 showed good adaptation, especially in situation b in nitrile 5 days, 3 mycelial inoculums and 54 μL of benzonitrile for microbial growth, resulting in 1.83 ± 0.03 g of wet biomass, confirming the efficiency of the selected mathematical model. A. niger Tiegh 8285 proved to be a promising bioremediation agent for benzonitrile.

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“…Pearson correlation analysis showed that some microbes are significantly associated with the above metabolites. According to previous report, Aspergillus is one of the most important strains commercially produced citric acid by starch or sucrose‐based medium fermentation (Aboyeji et al., 2020). It is known that honey contains a high amount of sucrose and thus is a good source for Aspergillus to produce citric acid.…”

Section: Discussionmentioning

confidence: 99%

Chemical, microbial, and metabolic analysis of Taisui cultured in honey solution

Chen

Zheng

Zhang

et al. 2021

Food Science & Nutrition

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Taisui, a special substance occasionally found in China, can now be artificially cultured. In order to evaluate the safety of an artificially cultured Taisui (acTS) and develop it into fermented, functional food or oral liquid, the macronutrients, trace elements, microbial community, and extracellular metabolites of Taisui have been investigated in this study. Results showed that the concentrations of total carbohydrates, protein, fat, total ash, and moisture of wet acTS were 2.13 g/100 g, 0.13 g/100 g, 0.07 g/100 g, 0.04 g/100 g, and 88.3%, respectively. The concentrations of top three trace elements of K, Ca, and P, are 1,424.92 mg/kg, 159.96 mg/kg, and 67.89 mg/kg, respectively. Proteobacteria, Euryarchaeota, and Ascomycota were the dominant phyla of bacteria, archaea, and fungi, respectively. Uncultured_bacterium_f_Anaerolineaceae, Alcaligenes, and Ochrobactrum were the three most abundant genera of bacteria; Methanosaeta, Methanosphaera, and Natronomonas, the most abundant genera of archaea; Zygosaccharomyces, Mortierella, and Fusarium, the most abundant genera of fungi. There were 311 metabolites increased in acTS. Most of the metabolites are beneficial to human. These metabolites can be contributed to microbes in acTS. In conclusion, acTS is not a good source of macronutrients and of trace elements, while the safeness of some microorganisms in acTS is also unknown. Nevertheless, it still provides some probiotics and beneficial metabolites for human. It is thus possible to develop acTS into foods when the safety of each microorganism is proved.

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Optimization of media components and fermentation conditions for citric acid production from sweet potato peel starch hydrolysate by Aspergillus niger

Cited by 21 publications

References 17 publications

Mathematical Model for Scaling up Bioprocesses Using Experiment Design Combined with Buckingham Pi Theorem

Mathematical Model for Scaling up Bioprocesses Using Experiment Design Combined with Buckingham Pi Theorem

Potential of Aspergillus niger Tiegh 8285 in the bioremediation of water contaminated with benzonitrile

Chemical, microbial, and metabolic analysis of Taisui cultured in honey solution

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