Optimization of microfluidic particle sorters based on dielectrophoresis

Nieuwenhuis, J.H.; Jachimowicz, A.; Svasek, P.; Vellekoop, Michael J.

doi:10.1109/jsen.2005.844333

Cited by 26 publications

(28 citation statements)

References 15 publications

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“…Note that H (1) 1 and H (2) 1 are the first-order Hankel functions of the first and second kind, respectively, and γ = (iRe) 1/2 . When streamfunction is expressed in the inertial reference frame (in which the cylinder is in motion and the fluid at rest at infinity), the first term in (A11) is cancelled by the first-order modification in the change of reference frame equation (7).…”

Section: Appendix: Flow Generated By Circular Cylinder In Oscillatorymentioning

confidence: 99%

“…Techniques for separating, focusing, and transporting small-sized particles in an aqueous environment have matured in recent years, motivated primarily by technology needs such as drug delivery, cell processing, and microfluidic devices. Some of the most notable and effective methods are based on lasers, [1][2][3] ultrasonics, 4, 5 dielectrophoresis, 6,7 and inertial hydrodynamic effects. 8,9 Another appealing option for particle manipulation is based on the notion of steady streaming.…”

Section: Introductionmentioning

confidence: 99%

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Inertial particle trapping in viscous streaming

et al. 2013

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The motion of an inertial particle in a viscous streaming flow of Reynolds number order 10 is investigated theoretically and numerically. The streaming flow created by a circular cylinder undergoing rectilinear oscillation with small amplitude is obtained by asymptotic expansion from previous work, and the resulting velocity field is used to integrate the Maxey-Riley equation with the Saffman lift for the motion of an inertial spherical particle immersed in this flow. It is found that inertial particles spiral inward and become trapped inside one of the four streaming cells established by the cylinder oscillation, regardless of the particle size, density and flow Reynolds number. It is shown that the Faxén correction terms divert the particles from the fluid particle trajectories, and once diverted, the Saffman lift force is most responsible for effecting the inward motion and trapping. The speed of this trapping increases with increasing particle size, decreasing particle density, and increasing oscillation Reynolds number. The effects of Reynolds number on the streaming cell topology and the boundaries of particle attraction are also explored. It is found that particles initially outside the streaming cell are repelled by the flow rather than trapped.

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Section: Appendix: Flow Generated By Circular Cylinder In Oscillatorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inertial particle trapping in viscous streaming

et al. 2013

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“…Thus, the development of high-resolution cell patterning, which is also capable of rapidly controlling multiple types of cells with good cell viability to preserve cell-cell interactions as well as potentially modulating cell behaviour, is important and challenging. 20 Compared with the passive cell-patterning techniques addressed above, an active manipulation method, dielectrophoresis (DEP), 21,22 has been recently widely used and demonstrated with the functions of trapping, [23][24][25] separation, 26,27 sorting, 28,29 and handling 30 for beads, specific bioparticles, and even neural stem cells. 31 For rapid manipulation and patterning on delicate cells like liver cells, our earlier efforts have been demonstrated by taking advantage of negative DEP force for cell patterning and positioning.…”

Section: Introductionmentioning

confidence: 99%

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

et al. 2013

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A lobule-mimetic cell-patterning technique for on-chip reconstruction of centimetre-scale liver tissue of heterogeneous hepatic and endothelial cells via an enhanced field-induced dielectrophoresis (DEP) trap is demonstrated and reported. By mimicking the basic morphology of liver tissue, the classic hepatic lobule, the lobule-mimetic-stellate-electrodes array was designed for cell patterning. Through DEP manipulation, well-defined and enhanced spatial electric field gradients were created for in-parallel manipulation of massive individual cells. With this liver-cell patterning labchip design, the original randomly distributed hepatic and endothelial cells inside the microfluidic chamber can be manipulated separately and aligned into the desired pattern that mimicks the morphology of liver lobule tissue. Experimental results showed that both hepatic and endothelial cells were orderly guided, snared, and aligned along the field-induced orientation to form the lobule-mimetic pattern. About 95% cell viability of hepatic and endothelial cells was also observed after cell-patterning demonstration via a fluorescent assay technique. The liver function of CYP450-1A1 enzyme activity showed an 80% enhancement for our engineered liver tissue (HepG2+HUVECs) compared to the non-patterned pure HepG2 for two-day culturing.

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“…On the contrary, the intensity and direction of a uniformed electric field stays constant. A non-uniform electric field can be generated by patterning different shapes of electrodes [21] or insulating materials to alter the electric field lines [22]. In general, whether the electric field is uniform can be judged by the electric field lines.…”

Section: Depp Methods 21 Dep Phenomenonmentioning

confidence: 99%

An experimental investigation of flat polishing with dielectrophoretic (DEP) effect of slurry

Zhao

Deng

Yuan

et al. 2016

Int J Adv Manuf Technol

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Dielectrophoresis polishing (DEPP) is a novel flat polishing technology which utilizes the dielectrophoretic (DEP) effect to reduce the centrifugal force on the slurry and to obtain a higher polishing efficiency. The mechanism of the DEPP was analyzed in this paper; the motion of slurry being acted upon by DEP force in non-uniform electric field was captured in real-time with a specially designed video recording system to show the influence of electric field intensity and frequency upon DEP force. DEPP and traditional CMP were investigated. These processes were carried out in sequence on the same machine with the same slurry. Compared with traditional CMP, the efficiency of DEPP was improved by about onefold and the better surface uniformity of silicon wafer was obtained. The final surface roughness Ra of silicon wafer was measured at 1.2 nm.

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Optimization of microfluidic particle sorters based on dielectrophoresis

Cited by 26 publications

References 15 publications

Inertial particle trapping in viscous streaming

Inertial particle trapping in viscous streaming

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

An experimental investigation of flat polishing with dielectrophoretic (DEP) effect of slurry

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