This paper presents a method for controlling and operating a multi-chillers system: (1) Model-based control approach was used by MATLAB/SIMULINK to model a building containing two non-identical chillers depending on thermal loads. (2) ON/OFF all chillers alternately using the model reinforcement learning controller (RL-control) to select the appropriate chiller for the building conditioning process. The results were in terms of energy efficiency and performance of the enhanced learning control for the chiller, and a control unit signal (PID) was applied to make a comparison with the signals of energy, power, and temperatures. After comparison, it was found that the energy saving through the proposed controller is 45% of the traditional (PID) strategy, where can the proposed strategy control for the chiller appropriate for the building's conditioning process.