2024
DOI: 10.1098/rsif.2024.0078
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Optimization of periodic treatment strategies for bacterial biofilms using an agent-based in silico approach

Johanna A. Blee,
Thomas E. Gorochowski,
Sabine Hauert

Abstract: Biofilms are responsible for most chronic infections and are highly resistant to antibiotic treatments. Previous studies have demonstrated that periodic dosing of antibiotics can help sensitize persistent subpopulations and reduce the overall dosage required for treatment. Because the dynamics and mechanisms of biofilm growth and the formation of persister cells are diverse and are affected by environmental conditions, it remains a challenge to design optimal periodic dosing regimens. Here, we develop a comput… Show more

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