“…Over the past two decades, we have witnessed a dramatic rise in opioid use, with many unintended consequences, such as opioid overdose, misuse, related utilization of hospitals, and even death, particularly in North America [ 3 , 4 , 5 ]. According to these negative consequences of opioid use, the United States government declared an opioid crisis and introduced various strategies to regulate opioid prescriptions, including prescription drug monitoring programs, lock-in programs, and opioid rescheduling [ 6 , 7 , 8 ]. The number of deaths related to prescription opioids has decreased (17,029 in 2017 vs. 14,139 in 2019) due to these various efforts, but the opioid crisis is still ongoing [ 9 ].…”