“…Different methods of experimental design have been used in various studies, such as orthogonal array based on Taguchi [3], [12], [20], [21], factorial design [22], central composite design [22]- [24], response surface methodology [23], [25], [26] and D-optimal design [27]. One of the drawbacks of full factorial design is that it requires a large number of trials, which can be costly and time consuming [3].…”