Optimization of processing parameters and conditioning for efficient bone tissue ablation by femtosecond laser

Al‐Bourgol, Samy; Gemini, Laura; Fauçon, Marc; Machinet, Guillaume; Kling, Rainer

doi:10.1117/12.2608731

Cited by 2 publications

(6 citation statements)

References 21 publications

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“…However, its main drawback lies in the limited material removal rate (MRR), significantly lower than mechanical processes. Consequently, researchers are focusing on maximizing MRR by optimizing laser and ablation parameters 7,10,[20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

“…Over the past decade, the integration of ultrashort laser technology into surgical tools has been a persistent pursuit. Researchers have explored its capabilities across various fronts [1][2][3][4][5] , with particular interest in bone ablation or laser osteotomy [6][7][8][9][10] . Unlike conventional mechanical methods, which suffer from poor spatial resolution and risk bone damage [11][12][13] , ultrashort laser ablation, owing to the nature of its process [17][18][19] , offers superior precision and minimal thermal impact 5,10,[14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

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Design of an ultrafast laser surgical probe towards maximum achievable MRR

Mishra,

Andrus,

Roy

et al. 2024

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXIV

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The major advancements in ultrafast laser ablation technology are revolutionizing surgical precision and minimizing thermal impact compared to traditional methods. However, the primary challenge hindering widespread clinical adoption has been the slow material removal rate (MRR). Towards this gap, a compact fiberbased laser delivery system has been developed, boasting an impressive 82-fold increase in MRR over the previous femtosecond laser surgical probes. This benchtop setup utilizes a hollow-core Kagome fiber (NA≈0.02) coupled to a high-power Yb-doped fiber laser (λ=1035 nm) to deliver laser pulses onto the sample. Employing a piezoscanned Lissajous-based beam steering mechanism, the system achieves efficient distribution of ultrashort pulses onto the target surface. Remarkably, the system maintains a high transmission efficiency of 74% while operating at peak intensities, with no components exhibiting nonlinear behavior. For a FOV scan width of 550 µm, the logarithmic relationship between the ablation depth and laser fluence was determined for two different translational velocities. The system achieved material removal rates of ~10.7 mm 3 /min for the maximum applied laser fluence of 9.3 J/cm 2 , without initiating carbonization. Moreover, by fine-tuning laser parameters, the system can swiftly create clean-cut trenches of significant dimensions, 3 x 3 mm 2 size and ~1 mm deep, mimicking conventional surgical procedures such as spinal decompression within a minute, all without carbonization or tissue damage. This remarkable achievement underscores the reliability and potential of ultrashort-laser ablation techniques for a wide array of surgical interventions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design of an ultrafast laser surgical probe towards maximum achievable MRR

Mishra,

Andrus,

Roy

et al. 2024

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXIV

View full text Add to dashboard Cite

show abstract

“…The current mechanical processes employed in cutting the bones, not only lack spatial resolution but also possess a high potential for incurring permanent damage to the bone [11][12][13] . Ultrashort laser ablations provide relief on both ends-spatial resolution, being an order of magnitude greater than the mechanical process, and negligible thermal damage 5,10,[14][15][16] , owing to the nature of its ablation process [17][18][19] . However, the only major drawback of ultrashort-laser ablations is the limited material removal rate (MRR), which is significantly small in comparison to conventional mechanical processes.…”

Section: Introductionmentioning

confidence: 99%

“…However, the only major drawback of ultrashort-laser ablations is the limited material removal rate (MRR), which is significantly small in comparison to conventional mechanical processes. Thus, maximizing the MRR by optimizing the laser and ablation-associated parameters becomes the major aim of many researchers in this field 7,10,[20][21][22][23] . Some medical conditions, such as lumbar/thoracic stenosis [24][25][26] , occur in very tight and closely spaced environments, where the deployment of mechanical tools inadvertently causes a dural tear or even bone damage.…”

Section: Introductionmentioning

confidence: 99%

“…Researchers have tried to demonstrate its strength in many affronts [1][2][3][4][5] . However, one of the major attractions, regarding the application of ultrashort-lasers, has been bone ablation or laser-osteotomy [6][7][8][9][10] . The current mechanical processes employed in cutting the bones, not only lack spatial resolution but also possess a high potential for incurring permanent damage to the bone [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Optimization of laser parameters for ultrashort-laser spinal surgeries

Mishra

Andrus

Roy

et al. 2023

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXIII

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Ultrafast laser ablation supersedes conventional surgical techniques in terms of precision and thermal load generation. However, the main limiting criterion of the application of laser ablation techniques to surgeries has been the low material removal rate (MRR). In efforts to bridge the gap, a benchtop fiber-baser laser delivery system has been developed which demonstrated a MRR increase of ~15 times over the previously reported fs-laser surgical probes. The benchtop optical setup incorporates a hollow-core Kagome fiber (NA≈0.02) delivering high-power laser pulses from the Yb-doped fiber laser (λ=1035 nm) source to the sample. A Lissajous-based beam steering mechanism was employed to distribute the ultrashort laser pulses on the sample. The overall transmission efficiency of the system was 59%, with none of the components exhibiting any non-linear behavior at high peak intensities. For a FOV scan width of 250 m, the logarithmic relationship between the ablation depth and laser fluence was determined for two different translational velocities. The system achieved material removal rates of ~2 mm 3 /min for the maximum applied laser fluence of 18.9 J/cm 2 , without initiating carbonization. Additionally, optimized laser parameters were implemented to achieve a cleancut trench of 3 x 0.8 m 2 size and ~1.22 mm deep in under 3 minutes of laser exposure, which is within the surgical time bounds of a conventional spinal decompression technique. The fact that the trench is devoid of any carbonized section or unhealthy tissue, and was created without any irrigation setting only increases the reliability and viability of the ultrashort-laser ablation technique in surgical applications.

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Optimization of processing parameters and conditioning for efficient bone tissue ablation by femtosecond laser

Cited by 2 publications

References 21 publications

Design of an ultrafast laser surgical probe towards maximum achievable MRR

Design of an ultrafast laser surgical probe towards maximum achievable MRR

Optimization of laser parameters for ultrashort-laser spinal surgeries

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