Optimization of production conditions for mushroom polysaccharides with high yield and antitumor activity

Zhang, Bing-Zhao; Yan, Peisheng; Chen, Hao; He, Jian

doi:10.1016/j.carbpol.2011.11.042

Cited by 32 publications

(17 citation statements)

References 26 publications

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“…Cordyceps, a well-known and valued Chinese medicinal mushroom, has various biological and pharmacological functions such as anti-tumor, antioxidant, antiaging, anti-inammatory, and immunity improving qualities. 1,2 Although C. gunnii and Cordyceps sinensis are different species, they display similar pharmacological activities, 3,4 which is generally attributed to the presence of essential bioactive ingredients. These include polysaccharides, cordycepic acid, cordycepin, superoxide dismutase (SOD), and amino acids.…”

Section: Introductionmentioning

confidence: 99%

“…26 The growth inhibitory rates of the crude polysaccharides to human gastric cancer cells were evaluated in vitro by MTT assay. 3 The polysaccharide of strain FK1 was extracted from the mycelium free supernatant by boiling water method and evaluated for antitoxicity effect on two human cancer cell lines: HeLa cell line and lymphoblastoid cell line (LCL) by MTT method. 27 The antitumor activities of Ganoderma lucidum polysaccharide to the human breast cancer cell (MDA-MB-231) in vitro was evaluated by MTT assay.…”

Section: Introductionmentioning

confidence: 99%

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The effect of fermentation conditions on the structure and anti-tumor activity of polysaccharides from Cordyceps gunnii

Liu

Kang

et al. 2019

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of fermentation conditions on the structure and anti-tumor activity of polysaccharides from Cordyceps gunnii

Liu

Kang

et al. 2019

RSC Adv.

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“…Polysaccharides isolated from plants have attracted a large amount of research attention due to their broad spectrum of therapeutic properties and their relatively low toxicity (11)(12)(13). In modern pharmacological studies, polysaccharides isolated from plants have been shown to carry out anti-inflammatory, anti-oxidant and antitumor activities (14)(15)(16). However, to the best of our knowledge, no previous studies have been conducted on the effects of BCBP on chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

Effects of Bauhinia championii (Benth.) Benth. polysaccharides on the proliferation and cell cycle of chondrocytes

Cai

et al. 2013

Molecular Medicine Reports

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It has been recently shown that polysaccharides isolated from plants exhibit a number of beneficial therapeutic properties. Bauhinia championii (Benth.) Benth. has been widely used for the clinical treatment of knee osteoarthritis (OA) in China. However, the underlying molecular mechanisms of knee OA treatment have yet to be elucidated. In the present study, we investigated the effects of Bauhinia championii (Benth.) Benth. polysaccharides (BCBPs) on the proliferation and cell cycle of chondrocytes on 4-week-old male Sprague Dawley rats. Immunohistochemical staining was used to identify chondrocytes and an MTT assay was used to evaluate cell viability. Flow cytometry was used for cell cycle analysis. The mRNA and protein expression levels of cyclin D1, CDK4 and CDK6 in chondrocytes were detected using reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis, respectively. The data demonstrate that BCBP treatment increased the viability of chondrocytes. In addition, BCBP treatment reduced the cell population in the G0/G1 phase, whereas the cell population was increased in the S phase. Furthermore, BCBP treatment enhanced the expression of cyclin D1, CDK4 and CDK6. These results indicate that BCBP treatment promotes cell proliferation by accelerating the G1/S transition.

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“…Polysaccharides derived from fruiting bodies and fermented broths of edible/medicinal mushrooms have been increasingly studied in recent years due to their potential antioxidant properties [ 10 , 12 , 13 ]. These properties have driven research into learning more about production, extraction, and additional bioactivities of polysaccharides [ 10 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Cultural Conditions for Antioxidant Exopolysaccharides fromXerocomus badiusGrown in Shrimp Byproduct

Gao

Yan

Liu

et al. 2016

BioMed Research International

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To optimize the production conditions for exopolysaccharides with higher antioxidant activities from Xerocomus badius cultured in shrimp byproduct medium, Plackett-Burman design, path of steepest ascent, and response surface methodology were explored. Based on the results of Plackett-Burman design and path of steepest ascent, a Box-Behnken design was applied to optimization and the regression models. The optimal cultural condition for high yield and antioxidant activity of the exopolysaccharides was determined to be 10.347% of solid-to-liquid ratio, a 4.322% content of bran powder, and a 1.217% concentration of glacial acetic acid. Culturing with the optimal cultural conditions resulted in an exopolysaccharides yield of 4.588 ± 0.346 g/L and a total antioxidant activity of 2.956 ± 0.105 U/mg. These values are consistent with the values predicted by the corresponding regression models (RSD < 5%).

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Optimization of production conditions for mushroom polysaccharides with high yield and antitumor activity

Cited by 32 publications

References 26 publications

The effect of fermentation conditions on the structure and anti-tumor activity of polysaccharides from Cordyceps gunnii

The effect of fermentation conditions on the structure and anti-tumor activity of polysaccharides from Cordyceps gunnii

Effects of Bauhinia championii (Benth.) Benth. polysaccharides on the proliferation and cell cycle of chondrocytes

Optimization of Cultural Conditions for Antioxidant Exopolysaccharides fromXerocomus badiusGrown in Shrimp Byproduct

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