Optimization of proton therapy eye-treatment systems toward improved clinical performances

Gnacadja, Eustache; Hernalsteens, Cédric; Boogert, Stewart; Flandroy, Quentin; Fuentes, Carolina; Nevay, Laurence; Pauly, Nicolas; Ramoisiaux, E; Shields, William; Tesse, Robin; Roermund, Raphaël Van; Vanwelde, Marion

doi:10.1103/physrevresearch.4.013114

Cited by 4 publications

(10 citation statements)

References 22 publications

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“…The IBA eyeline has been previously designed [4] and experimentally optimized with an energy of 105 MeV at the nozzle entrance [5], leading to a maximum dose rate of 30 Gy/min, but with a DFO of only 3.2 mm. More recently, the different steps toward a numerical optimization for a smaller DFO (below 2 mm) has been presented in detail in [6], using Beam Delivery SIMulation (BDSIM) [7]. BDSIM is a geant4 based particle tracking and beam-matter interactions simulation code, that has already proven its ability to model low energy proton therapy systems [8].…”

Section: Introductionmentioning

confidence: 99%

“…Table 1 summarizes the clinical performances required during the optimization presented in ref. [6]. As discussed in [6], two designs of the IBA eyeline were studied.…”

Section: Introductionmentioning

confidence: 99%

“…[6]. As discussed in [6], two designs of the IBA eyeline were studied. The first design only uses the scattering and range shifting features of the system to optimize the nozzle, with at the end a maximum achievable dose rate of 17 Gy/min.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1 illustrates the BDSIM model of the nozzle as designed with this cylindrical beam stopping device. Evolution of the dose rate in function of clinical range, as calculated for the single scattering (blue) and the beam stop (red) designs in [6]. The maximum achievable dose rate with the beam stopper design is 42.4 Gy/min, while the single scattering maximum value is around 17 Gy/min.…”

Section: Introductionmentioning

confidence: 99%

“…As the beam propagates, the hole is progressively filled by the particles due to their transverse angle, and a transversally flat profile is obtained at isocenter. The design parameters obtained in [6] (scattering foil, beam stopper radius and position) when optimizing the nozzle with the beam stopper are summarized in table 2. Figure 2 shows the results of the dose rate optimization using both designs, as obtained in [6].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Upgrade of a proton therapy eye treatment nozzle using a cylindrical beam stopping device for enhanced dose rate performances

Gnacadja

Hernalsteens

Pauly

et al. 2023

J. Phys.: Conf. Ser.

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Proton therapy is a well established treatment method for ocular cancerous diseases. General-purpose multi-room systems which comprise eye-treatment beamlines must be thoroughly optimized to achieve the performances of fully dedicated systems in terms of depth-dose distal fall-off, lateral penumbra, and dose rate. For eye-treatment beamlines, the dose rate is one of the most critical clinical performances, as it directly defines the delivery time of a given treatment session. This delivery time must be kept as low as possible to reduce uncertainties due to undesired patient movement. We propose an alternative design of the Ion Beam Applications (IBA) Proteus Plus (P+) eye treatment beamline, which combines a beam-stopping device with the already existing scattering features of the beamline. The design is modelled with Beam Delivery SIMulation (BDSIM), a Geant4-based particle tracking and beam-matter interactions Monte-Carlo code, to demonstrate that it increases the maximum achievable dose rate by up to a factor 3 compared to the baseline configuration. An in-depth study of the system is performed and the resulting dosimetric properties are discussed in detail.

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Section: Introductionmentioning

confidence: 99%

“…Table 1 summarizes the clinical performances required during the optimization presented in ref. [6]. As discussed in [6], two designs of the IBA eyeline were studied.…”

Section: Introductionmentioning

confidence: 99%