Optimization of reaction conditions for enzymatic synthesis of palm fatty hydrazides using response surface methodology

Maznee, T. I. Tuan Noor; Hazimah, A. H.; Zin, W Y Wan Md

doi:10.5650/jos.61.297

Cited by 4 publications

References 13 publications

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Lipase‐catalyzed hydrazine insertion for the synthesis of N′‐alkyl benzohydrazides

et al. 2022

Biotech and App Biochem

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N′-alkyl benzohydrazides are classic organic compounds that have been widely utilized in organic chemistry. In this study, an efficient method was developed for the synthesis of N′-alkyl benzohydrazides by hydrazine insertion catalyzed by lipase. Under the optimal conditions (Morita-Baylis-Hillman ketone [1 mmol], phenylhydrazine [1.3 mmol], N,N-dimethylformamide [2 ml], lipase [20 mg], room temperature, 12 h), satisfactory yields (71-97%) and substrate tolerance were obtained when porcine pancreatic lipase was used as biocatalyst. These findings imply the great potential for the lipase-catalyzed synthesis of N′-alkyl benzohydrazides and extend the utilization of lipase in organic chemistry.

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Lipase‐catalyzed hydrazine insertion for the synthesis of N′‐alkyl benzohydrazides

et al. 2022

Biotech and App Biochem

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Dynamic Response Surface Models: A Data-Driven Approach for the Analysis of Time-Varying Process Outputs

Klebanov

Georgakis

2016

Ind. Eng. Chem. Res.

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In a recent publication (Ind. Eng. Chem. Res. 2013, 52 (35), 12369) we generalized the classic design of experiments (DoE) methodology by introducing the Design of Dynamic Experiments (DoDE), allowing for the systematic design of experiments involving time-varying inputs. Here, we expand the response surface model (RSM) methodology, used in DoE and DoDE problems, so that it describes the time-evolution of the process, not just the results at the end of the experiment. We apply this generalized type of RSM model, to be denoted by DRSM, to three example processes; a nonisothermal batch reactor with a simple reaction, an isothermal semibatch reactor with several reactions, and a semibatch penicillin fermentation process. Using a limited number of online measurements at prespecified equidistant time instants, we are able to quickly and accurately represent the time evolution of the process output through these simple interpolative data-driven models. The ever-increasing availability of time-resolved measurements is expected to make the proposed approach widely useful.

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Clay modification by epoxidized fatty hydrazides synthesized from palm oil

Jamingan¹,

Yunus²,

Abdullah³

et al. 2019

AIP Conference Proceedings

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Optimization of reaction conditions for enzymatic synthesis of palm fatty hydrazides using response surface methodology

Cited by 4 publications

References 13 publications

Lipase‐catalyzed hydrazine insertion for the synthesis of N′‐alkyl benzohydrazides

Lipase‐catalyzed hydrazine insertion for the synthesis of N′‐alkyl benzohydrazides

Dynamic Response Surface Models: A Data-Driven Approach for the Analysis of Time-Varying Process Outputs

Clay modification by epoxidized fatty hydrazides synthesized from palm oil

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